TY - JOUR
T1 - Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis
AU - Jia, Wei
AU - Li, Yitao
AU - Cheung, Kenneth C. P.
AU - Zheng, Xiaojiao
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (82122012, 82270917) and Shanghai Research Center for Endocrine and Metabolic Diseases (2022ZZ01002).
Publisher Copyright:
© 2023, Science China Press.
PY - 2024/5
Y1 - 2024/5
N2 - Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabolized, and reabsorbed, with a portion entering the vascular circulation and distributing systemically. This allows BAs to interact with receptors in all major organs, leading to organ-organ interactions that regulate both local and global metabolic processes, as well as the immune system. This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation, including in the brain, heart, liver, intestine, eyes, skin, adipose tissue, and muscle. Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.
AB - Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabolized, and reabsorbed, with a portion entering the vascular circulation and distributing systemically. This allows BAs to interact with receptors in all major organs, leading to organ-organ interactions that regulate both local and global metabolic processes, as well as the immune system. This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation, including in the brain, heart, liver, intestine, eyes, skin, adipose tissue, and muscle. Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.
KW - bile acid
KW - immunity
KW - metabolism
KW - whole body
UR - http://www.scopus.com/inward/record.url?scp=85166207268&partnerID=8YFLogxK
U2 - 10.1007/s11427-023-2353-0
DO - 10.1007/s11427-023-2353-0
M3 - Journal article
SN - 1674-7305
VL - 67
SP - 865
EP - 878
JO - Science China Life Sciences
JF - Science China Life Sciences
IS - 5
ER -
