Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

Wei Jia*, Yitao Li, Kenneth C. P. Cheung, Xiaojiao Zheng*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

15 Citations (Scopus)


Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabolized, and reabsorbed, with a portion entering the vascular circulation and distributing systemically. This allows BAs to interact with receptors in all major organs, leading to organ-organ interactions that regulate both local and global metabolic processes, as well as the immune system. This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation, including in the brain, heart, liver, intestine, eyes, skin, adipose tissue, and muscle. Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.
Original languageEnglish
Pages (from-to)865–878
Number of pages14
JournalScience China Life Sciences
Issue number5
Early online date27 Jul 2023
Publication statusPublished - May 2024

User-Defined Keywords

  • bile acid
  • immunity
  • metabolism
  • whole body


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