BF3 center dot Et2O Promoted Sulfuration of Steroidal Sapogenins

Jun Wang*, Jingjing Wu, Weisheng Tian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A novel difunctionalization reaction is described. It uses N-trifluoromethylthio-4-nitrophthalimide as the reagent, which serves as both the nitrogen and SCF3 sources. In the presence of DABCO (1,4-diazabicyclo[2.2.2]octane), the nitrogen and SCF3 groups can be incorporated into α,β-unsaturated carbonyl compounds easily and give versatile β-amino ketones and esters in good yields. This difunctionalization reaction features mild reaction conditions, high atom-economy, and efficient access to α-SCF3 amino acids.

Original languageEnglish
Pages (from-to)6090–6093
JournalChinese Journal of Chemistry
Volume17
Issue number24
DOIs
Publication statusPublished - 2015

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