TY - JOUR
T1 - BES1 Accumulates in the Nucleus in Response to Brassinosteroids to Regulate Gene Expression and Promote Stem Elongation
AU - Yin, Yanhai
AU - Wang, Zhi Yong
AU - Mora-Garcia, Santiago
AU - Li, Jianming
AU - Yoshida, Shigeo
AU - Asami, Tadao
AU - Chory, Joanne
N1 - This work was supported by a grant from the USDA (9935301-7903) to J.C. and the Howard Hughes Medical Institute. Y.Y. is supported in part by a National Research Service Award postdoctoral fellowship, Z.-Y. Wang by a fellowship from National Science Foundation, and S. M.-G. by a fellowship from the Human Frontier Science Program.
Publisher copyright:
© 2002 Cell Press. Published by Elsevier Inc. All rights reserved.
PY - 2002/4/19
Y1 - 2002/4/19
N2 - Plant steroid hormones, known as brassinosteroids (BRs), signal through a plasma membrane localized receptor kinase BRI1. We identified bes1, a semidominant suppressor of bri1, which exhibits constitutive BR response phenotypes including long and bending petioles, curly leaves, accelerated senescence, and constitutive expression of BR-response genes. BES1 accumulates in the nucleus in response to BRs. BES1 is phosphorylated and appears to be destabilized by the glycogen synthase kinase-3 (GSK-3) BIN2, a negative regulator of the BR pathway. These results establish a signaling cascade for BRs with similarities to the Wnt pathway, in which signaling through cell surface receptors leads to inactivation of a GSK-3 allowing accumulation of a nuclear protein that regulates target gene expression.
AB - Plant steroid hormones, known as brassinosteroids (BRs), signal through a plasma membrane localized receptor kinase BRI1. We identified bes1, a semidominant suppressor of bri1, which exhibits constitutive BR response phenotypes including long and bending petioles, curly leaves, accelerated senescence, and constitutive expression of BR-response genes. BES1 accumulates in the nucleus in response to BRs. BES1 is phosphorylated and appears to be destabilized by the glycogen synthase kinase-3 (GSK-3) BIN2, a negative regulator of the BR pathway. These results establish a signaling cascade for BRs with similarities to the Wnt pathway, in which signaling through cell surface receptors leads to inactivation of a GSK-3 allowing accumulation of a nuclear protein that regulates target gene expression.
UR - https://www.scopus.com/pages/publications/0037133960
U2 - 10.1016/S0092-8674(02)00721-3
DO - 10.1016/S0092-8674(02)00721-3
M3 - Journal article
C2 - 12007405
AN - SCOPUS:0037133960
SN - 0092-8674
VL - 109
SP - 181
EP - 191
JO - Cell
JF - Cell
IS - 2
ER -
