Based on bioinformatics approach to explore the novel targets and activity of multiple ingredients in Shuang-Huang-Lian (Using bioinformatics approach to explore the machanisms of a modern formula)

Hao Gu, Jian Li, Qi Zhang, Qiang Li, Miao Jiang, Aiping LYU, Cheng Ke Cai, Yun Wang*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

Abstract

Shuang-Huang-Lian (SHL) is a famous modern formula prepared from three medicinal herbs including Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae. Currently, SHL has been developed a variety of dosage forms due to its proved clinical efficacy. However, the in-depth research on targets and pharmacological mechanisms of SHL preparations was scarce. In the presented study, the bioinformatics approaches were adopted to integrate relevant data and biological information. As a result, a PPI network was built and the common topological parameters were characterized. The reuslts suggested that the PPI network of SHL exhibited a scale-free property and modular architecture. The drug target network of SHL was structured with 21 functional clusters as modules naturally. According to certain modules and pharmacological effects distribution, an anti-tumor effect and protented durg targets were predicted. In conclutions, a bioinformatics approach was established for exploring the drug targets and pharmacological activity distribution. The results offered a novel anti-tumor effect of SHL and provide a clue for further research and development.

Original languageEnglish
Title of host publicationProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
EditorsHuiru Zheng, Xiaohua Tony Hu, Yadong Wang, Jin-Kao Hao, David Gilbert, Daniel Berrar, Kwang-Hyun Cho, Werner Dubitzky
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages33-34
Number of pages2
ISBN (Electronic)9781479956692
DOIs
Publication statusPublished - 29 Dec 2014
Event2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 - Belfast, United Kingdom
Duration: 2 Nov 20145 Nov 2014

Publication series

NameProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

Conference

Conference2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Country/TerritoryUnited Kingdom
CityBelfast
Period2/11/145/11/14

Scopus Subject Areas

  • Biomedical Engineering
  • Health Informatics

User-Defined Keywords

  • drug target network
  • PPI network
  • Shuang-Huang-Lian

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