@inproceedings{8729cd4d201147cfbc38fd2beb16a9fa,
title = "Based on bioinformatics approach to explore the novel targets and activity of multiple ingredients in Shuang-Huang-Lian (Using bioinformatics approach to explore the machanisms of a modern formula)",
abstract = "Shuang-Huang-Lian (SHL) is a famous modern formula prepared from three medicinal herbs including Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae. Currently, SHL has been developed a variety of dosage forms due to its proved clinical efficacy. However, the in-depth research on targets and pharmacological mechanisms of SHL preparations was scarce. In the presented study, the bioinformatics approaches were adopted to integrate relevant data and biological information. As a result, a PPI network was built and the common topological parameters were characterized. The reuslts suggested that the PPI network of SHL exhibited a scale-free property and modular architecture. The drug target network of SHL was structured with 21 functional clusters as modules naturally. According to certain modules and pharmacological effects distribution, an anti-tumor effect and protented durg targets were predicted. In conclutions, a bioinformatics approach was established for exploring the drug targets and pharmacological activity distribution. The results offered a novel anti-tumor effect of SHL and provide a clue for further research and development.",
keywords = "drug target network, PPI network, Shuang-Huang-Lian",
author = "Hao Gu and Jian Li and Qi Zhang and Qiang Li and Miao Jiang and Aiping LYU and Cai, {Cheng Ke} and Yun Wang",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 ; Conference date: 02-11-2014 Through 05-11-2014",
year = "2014",
month = dec,
day = "29",
doi = "10.1109/BIBM.2014.6999318",
language = "English",
series = "Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014",
publisher = "IEEE",
pages = "33--34",
editor = "Zheng, {Huiru Jane} and Xiaohua Hu and Daniel Berrar and Yadong Wang and Werner Dubitzky and Jin-Kao Hao and Kwang-Hyun Cho and David Gilbert",
booktitle = "Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014",
address = "United States",
}