Base-promoted O-deprotonation/alkylation reaction of P(O)-OH compounds with alkyl halides

Biquan Xiong, Qianqian Ye, Xiaofeng Feng, Longzhi Zhu, Tieqiao Chen, Yongbo Zhou, Chak Tong AU, Shuang Feng Yin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A novel base-promoted O-deprotonation/alkylation reaction of P(O)-OH compounds with alkyl halides has been developed. The protocol is practical, representing a simple way to produce a broad spectrum of functionalized phosphinates, phosphonates, and phosphates from basic starting materials with good to excellent yields. A plausible mechanism was proposed for this reaction.

Original languageEnglish
Pages (from-to)9057-9063
Number of pages7
JournalTetrahedron
Volume70
Issue number47
DOIs
Publication statusPublished - 25 Nov 2014

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Alkyl halides
  • Base-promoted
  • O-Deprotonation/alkylation reaction
  • P(O)-OH compounds

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