TY - JOUR
T1 - Balancing mTOR signaling and autophagy in the treatment of Parkinson’s disease
AU - Zhu, Zhou
AU - Yang, Chuanbin
AU - Iyaswamy, Ashok
AU - Krishnamoorthi, Senthilkumar
AU - Sreenivasmurthy, Sravan Gopalkrishnashetty
AU - Liu, Jia
AU - Wang, Ziying
AU - Tong, Chun Kit Benjamin
AU - Song, Juxian
AU - Lu, Jiahong
AU - Cheung, King-Ho
AU - Li, Min
N1 - Funding Information:
Funding: This study was supported by the National Natural Science Foundation of China (81703487 and 81773926), the Hong Kong General Research Fund (RGC/GRF/12100618, RGC/GRF/12101417), the Hong Kong Health and Medical Research Fund (HMRF/15163481, HMRF14150811) and the research fund from the Hong Kong Baptist University (HKBU/RC-IRCs/17-18/03, HKBU/RC-IRMS/15-16/04, FRGI/17-18/041, FRGII/17-18/021).
PY - 2019/2/1
Y1 - 2019/2/1
N2 - The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the activity of the unc51-like kinase 1 (ULK1) complex and vacuolar protein sorting 34 (VPS34) complex, and the intracellular distribution of TFEB/TFE3 and proto-lysosome tubule reformation. Parkinson’s disease (PD) is a serious, common neurodegenerative disease characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) and the accumulation of Lewy bodies. An increasing amount of evidence indicates that mTOR and autophagy are critical for the pathogenesis of PD. In this review, we will summarize recent advances regarding the roles of mTOR and autophagy in PD pathogenesis and treatment. Further characterizing the dysregulation of mTOR pathway and the clinical translation of mTOR modulators in PD may offer exciting new avenues for future drug development.
AB - The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the activity of the unc51-like kinase 1 (ULK1) complex and vacuolar protein sorting 34 (VPS34) complex, and the intracellular distribution of TFEB/TFE3 and proto-lysosome tubule reformation. Parkinson’s disease (PD) is a serious, common neurodegenerative disease characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) and the accumulation of Lewy bodies. An increasing amount of evidence indicates that mTOR and autophagy are critical for the pathogenesis of PD. In this review, we will summarize recent advances regarding the roles of mTOR and autophagy in PD pathogenesis and treatment. Further characterizing the dysregulation of mTOR pathway and the clinical translation of mTOR modulators in PD may offer exciting new avenues for future drug development.
KW - Autophagy
KW - mTOR
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85061393606&partnerID=8YFLogxK
U2 - 10.3390/ijms20030728
DO - 10.3390/ijms20030728
M3 - Review article
C2 - 30744070
AN - SCOPUS:85061393606
SN - 1661-6596
VL - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 3
M1 - 728
ER -
