Autophagy Receptors and Neurodegenerative Diseases

Zhiqiang Deng, Kerry Purtell, Veronik Lachance, Mitchell S. Wold, Shi Chen*, Zhenyu Yue*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

154 Citations (Scopus)

Abstract

Previously thought of as a nonselective digestion process, autophagy is now known to specifically degrade aggregated proteins and damaged cellular organelles through the action of autophagy receptors, which provides cellular quality control and maintains homeostasis. Autophagy receptors recognize and recruit specific cargoes to the autophagosome–lysosome pathway for degradation in ubiquitin-dependent and -independent manners, and their functions (in selective autophagy) are regulated by protein modifications, for example, phosphorylation and ubiquitination. Growing evidence has linked the genetic variants of autophagy receptors to neurodegenerative diseases and multiple experimental systems have validated their roles in modulating the disease process. Here, we review the recent advances in understanding the physiology and pathophysiology of autophagy receptors in selective autophagy, and discuss their potentials as therapeutic targets for neurodegenerative diseases.

Original languageEnglish
Pages (from-to)491-504
Number of pages14
JournalTrends in Cell Biology
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2017
Externally publishedYes

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