Abstract
A copper/(R)-DTBM-SEGPHOS-catalyzed enantioselective hydroamination of 2H-chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4-aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.
Original language | English |
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Pages (from-to) | 3202-3206 |
Number of pages | 5 |
Journal | ChemCatChem |
Volume | 12 |
Issue number | 12 |
DOIs | |
Publication status | Published - 18 Jun 2020 |