Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2 H ‐Chromenes

Qingjing Yang, Sifeng Li, Jun (Joelle) Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A copper/(R)-DTBM-SEGPHOS-catalyzed enantioselective hydroamination of 2H-chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4-aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.

Original languageEnglish
Pages (from-to)3202-3206
JournalChemCatChem
Volume12
Issue number12
DOIs
Publication statusPublished - 18 Jun 2020

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