Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2 H ‐Chromenes

Qingjing Yang; Sifeng Li; Jun (Joelle) Wang

doi:10.1002/cctc.202000601

Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2 H ‐Chromenes

Qingjing Yang, Sifeng Li, Jun (Joelle) Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A copper/(R)-DTBM-SEGPHOS-catalyzed enantioselective hydroamination of 2H-chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4-aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.

Original language	English
Pages (from-to)	3202-3206
Number of pages	5
Journal	ChemCatChem
Volume	12
Issue number	12
DOIs	https://doi.org/10.1002/cctc.202000601
Publication status	Published - 18 Jun 2020

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title = "Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2 H ‐Chromenes",

abstract = "A copper/(R)-DTBM-SEGPHOS-catalyzed enantioselective hydroamination of 2H-chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4-aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.",

author = "Qingjing Yang and Sifeng Li and Wang, {Jun (Joelle)}",

year = "2020",

month = jun,

day = "18",

doi = "10.1002/cctc.202000601",

language = "English",

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journal = "ChemCatChem",

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T1 - Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2 H ‐Chromenes

AU - Yang, Qingjing

AU - Li, Sifeng

AU - Wang, Jun (Joelle)

PY - 2020/6/18

Y1 - 2020/6/18

N2 - A copper/(R)-DTBM-SEGPHOS-catalyzed enantioselective hydroamination of 2H-chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4-aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.

AB - A copper/(R)-DTBM-SEGPHOS-catalyzed enantioselective hydroamination of 2H-chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4-aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.

U2 - 10.1002/cctc.202000601

DO - 10.1002/cctc.202000601

M3 - Article

VL - 12

SP - 3202

EP - 3206

JO - ChemCatChem

JF - ChemCatChem

SN - 1867-3880

IS - 12

ER -

Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2 H ‐Chromenes

Abstract

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