Asymmetric synthesis of 1,3- and 1,3,4-substituted pyrrolidines

Jing Lin, Wing Hong CHAN*, Albert W M LEE, Wai Yeung WONG, Pei Qiang Huang

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

10 Citations (Scopus)


Diastereoselective alkylation of N-acylnorbornene sultams 2 afforded a variety of enantiomerically pure products 3a-3e. Reduction with LiAlH4 (LAH) followed by ditosylation furnished chiral 1,4-ditosylates 5a-5e which underwent a cyclization reaction with primary amines to afford chiral 1,3- and 1,3,4-substituted pyrrolidines. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2949-2951
Number of pages3
JournalTetrahedron Letters
Issue number16
Publication statusPublished - 15 Apr 2000

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Asymmetric synthesis
  • Cyclization
  • Pyrrolidines
  • Sultams


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