Abstract
A Cu/CPA co-catalytic system has been developed for achieving the direct hydrophosphinylation of alkynes with phosphine oxides in delivering novel axially chiral phosphorus-containing alkenes in high yields and excellent enantioselectivities (up to 99 % yield and 99 % ee). DFT calculations were performed to elucidate the reaction pathway and the origin of enantiocontrol. This streamlined and modular methodology establishes a new platform for the design and application of new axially chiral styrene-phosphine ligands.
Original language | English |
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Article number | e202215820 |
Number of pages | 6 |
Journal | Angewandte Chemie. International Edition |
Volume | 62 |
Issue number | 3 |
Early online date | 24 Nov 2022 |
DOIs | |
Publication status | Published - 16 Jan 2023 |
Scopus Subject Areas
- General Chemistry
- Catalysis
User-Defined Keywords
- Axial Chirality
- Chiral Phosphoric Acid
- Copper
- Hydrophosphinylation
- Phosphine