@article{a08740849b574ff1a532b68167bf7b73,
title = "Asymmetric Hydrophosphinylation of Alkynes: Facile Access to Axially Chiral Styrene‐Phosphines",
abstract = "A Cu/CPA co-catalytic system has been developed for achieving the direct hydrophosphinylation of alkynes with phosphine oxides in delivering novel axially chiral phosphorus-containing alkenes in high yields and excellent enantioselectivities (up to 99 % yield and 99 % ee). DFT calculations were performed to elucidate the reaction pathway and the origin of enantiocontrol. This streamlined and modular methodology establishes a new platform for the design and application of new axially chiral styrene-phosphine ligands.",
keywords = "Axial Chirality, Chiral Phosphoric Acid, Copper, Hydrophosphinylation, Phosphine",
author = "Baohua Cai and Yuan Cui and Jian Zhou and Yong‐Bin Wang and Limin Yang and Bin Tan and Wang, {Jun Joelle}",
note = "Funding Information: This research was supported by CARF (Center for Advanced Research in Finance). Funding Information: We are grateful for financial support from the Research Grants Council of Hong Kong (GRF 12301821), the National Natural Science Foundation of China (NSFC 21971102, NSFC 22231004, NSFC 21825105, NSFC 22271071), Guangdong Provincial Key Laboratory of Catalysis (2020B121201002), Guangdong Innovative Program (2019BT02Y335), Shenzhen Science and Technology Program (KQTD20210811090112004), and Natural Science Foundation of Zhejiang Province (LY20B020010. Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",
year = "2023",
month = jan,
day = "16",
doi = "10.1002/anie.202215820",
language = "English",
volume = "62",
journal = "Angewandte Chemie. International Edition",
issn = "1433-7851",
publisher = "John Wiley & Sons Ltd.",
number = "3",
}
