Abstract
γ-Aminobutyric acid is a major inhibitory neurotransmitter in the mammalian central nervous system that plays a substantial role in brain disorders. γ-Amino phosphonic acid is a unique surrogate of both natural and unnatural γ-amino acid. Because of their unique biological activity, γ-amino acid and γ-amino phosphonic acid derivatives have attracted considerable attention. However, an efficient and straightforward method for constructing chiral γ-substituted-γ-amino acid and γ-amino phosphonic acid derivatives remains a long-standing challenge. Herein, a highly efficient, versatile, and universal Cu-catalyzed asymmetric hydroamination of cinnamyl esters, cinnamyl phosphonates, and cinnamyl phosphine oxides is presented for accessing γ-amino acid and γ-amino phosphonic acid derivatives in good yields with high levels of enantiocontrol and regioselectivity.
Original language | English |
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Pages (from-to) | 1901-1911 |
Number of pages | 11 |
Journal | CCS Chemistry |
Volume | 4 |
Issue number | 6 |
Early online date | 24 Aug 2021 |
DOIs | |
Publication status | Published - Jun 2022 |
Scopus Subject Areas
- Chemistry(all)
User-Defined Keywords
- amino phosphine
- asymmetric catalysis
- copper
- hydroamination
- γ-amino acid