Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

Alvaro A. Cruz; John H. Riley; Aruna T. Bansal; Eduardo V. Ponte; Adelmir Souza-Machado; Paula C.A. Almeida; Valmar Biao-Lima; Maggie Davis; Stewart Bates; Ian M. Adcock; Peter J. Sterk; Kian Fan Chung; ProAR Study Group; U-BIOPRED Study Groups; N. Alcantara-Neves; P. C.A. Almeida; L. Amorim; M. I. Araujo; K. C. Barnes; M. L. Barreto; E. Belitardo; V. Bião-Lima; L. Cardoso; P. A. Camargos; J. M. Chatkin; R. S. Costa; A. C.C. Coelho; P. J. Cooper; A. A. Cruz; C. S. Cruz; J. Cunha; J. V. de Jesus; J. Fernandes; R. A. Franco; I. Gomes-Filho; A. Lima-Matos; C. A. Figueiredo; M. A. Lessa; L. Lins; L. M. Mello; P. Moura-Santos; I. S. Muniz; I. Paixao-Araujo; G. P. Pinheiro; E. V. Ponte; L. C. Rodrigues; C. V.N. Santana; G. Santos-Lima; T. M.O. Souza; A. Souza-Machado; C. Souza-Machado; Yi-Ke GUO

doi:10.1016/j.rmed.2019.105817

Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

Alvaro A. Cruz^*, John H. Riley, Aruna T. Bansal, Eduardo V. Ponte, Adelmir Souza-Machado, Paula C.A. Almeida, Valmar Biao-Lima, Maggie Davis, Stewart Bates, Ian M. Adcock, Peter J. Sterk, Kian Fan Chung, ProAR Study Group, U-BIOPRED Study Groups, N. Alcantara-Neves, P. C.A. Almeida, L. Amorim, M. I. Araujo, K. C. Barnes, M. L. BarretoE. Belitardo, V. Bião-Lima, L. Cardoso, P. A. Camargos, J. M. Chatkin, R. S. Costa, A. C.C. Coelho, P. J. Cooper, A. A. Cruz, C. S. Cruz, J. Cunha, J. V. de Jesus, J. Fernandes, R. A. Franco, I. Gomes-Filho, A. Lima-Matos, C. A. Figueiredo, M. A. Lessa, L. Lins, L. M. Mello, P. Moura-Santos, I. S. Muniz, I. Paixao-Araujo, G. P. Pinheiro, E. V. Ponte, L. C. Rodrigues, C. V.N. Santana, G. Santos-Lima, T. M.O. Souza, A. Souza-Machado, C. Souza-Machado, Yi-Ke GUO

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

13 Citations (Scopus)

Abstract

Background: Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV₁ pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV₁/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

Original language	English
Article number	105817
Journal	Respiratory Medicine
Volume	161
DOIs	https://doi.org/10.1016/j.rmed.2019.105817
Publication status	Published - Jan 2020

Scopus Subject Areas

Pulmonary and Respiratory Medicine

User-Defined Keywords

Asthma
Biomarkers
Cohort studies
Cross sectional study
Disease management
Phenotypes

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10.1016/j.rmed.2019.105817

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Cruz, A. A., Riley, J. H., Bansal, A. T., Ponte, E. V., Souza-Machado, A., Almeida, P. C. A., Biao-Lima, V., Davis, M., Bates, S., Adcock, I. M., Sterk, P. J., Chung, K. F., ProAR Study Group, U-BIOPRED Study Groups, Alcantara-Neves, N., Almeida, P. C. A., Amorim, L., Araujo, M. I., Barnes, K. C., ... GUO, Y-K. (2020). Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status. Respiratory Medicine, 161, [105817]. https://doi.org/10.1016/j.rmed.2019.105817

@article{0c91e15c83834edbb7b450993b94af8b,

title = "Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status",

abstract = "Background: Asthma prevalence is 339 million globally. {\textquoteleft}Severe asthma{\textquoteright} (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.",

keywords = "Asthma, Biomarkers, Cohort studies, Cross sectional study, Disease management, Phenotypes",

author = "Cruz, {Alvaro A.} and Riley, {John H.} and Bansal, {Aruna T.} and Ponte, {Eduardo V.} and Adelmir Souza-Machado and Almeida, {Paula C.A.} and Valmar Biao-Lima and Maggie Davis and Stewart Bates and Adcock, {Ian M.} and Sterk, {Peter J.} and Chung, {Kian Fan} and {ProAR Study Group} and {U-BIOPRED Study Groups} and N. Alcantara-Neves and Almeida, {P. C.A.} and L. Amorim and Araujo, {M. I.} and Barnes, {K. C.} and Barreto, {M. L.} and E. Belitardo and V. Bi{\~a}o-Lima and L. Cardoso and Camargos, {P. A.} and Chatkin, {J. M.} and Costa, {R. S.} and Coelho, {A. C.C.} and Cooper, {P. J.} and Cruz, {A. A.} and Cruz, {C. S.} and J. Cunha and {de Jesus}, {J. V.} and J. Fernandes and Franco, {R. A.} and I. Gomes-Filho and A. Lima-Matos and Figueiredo, {C. A.} and Lessa, {M. A.} and L. Lins and Mello, {L. M.} and P. Moura-Santos and Muniz, {I. S.} and I. Paixao-Araujo and Pinheiro, {G. P.} and Ponte, {E. V.} and Rodrigues, {L. C.} and Santana, {C. V.N.} and G. Santos-Lima and Souza, {T. M.O.} and A. Souza-Machado and C. Souza-Machado and Yi-Ke GUO",

note = "Funding Information: For ProAR - Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico do Brasil (CNPq) – Grant # 471057/2014-2 , Funda{\c c}{\~a}o de Amparo a Pesquisa do Estado da Bahia (FAPESB) and GlaxoSmilthKline investigator initiated grant. For U-BIOPRED - IMI EU funded project (no. 115010 ). Funding Information: For ProAR - Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico do Brasil (CNPq) ? Grant # 471057/2014-2, Funda??o de Amparo a Pesquisa do Estado da Bahia (FAPESB) and GlaxoSmilthKline investigator initiated grant. For U-BIOPRED - IMI EU funded project (no. 115010).",

year = "2020",

month = jan,

doi = "10.1016/j.rmed.2019.105817",

language = "English",

volume = "161",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

}

Cruz, AA, Riley, JH, Bansal, AT, Ponte, EV, Souza-Machado, A, Almeida, PCA, Biao-Lima, V, Davis, M, Bates, S, Adcock, IM, Sterk, PJ, Chung, KF, ProAR Study Group, U-BIOPRED Study Groups, Alcantara-Neves, N, Almeida, PCA, Amorim, L, Araujo, MI, Barnes, KC, Barreto, ML, Belitardo, E, Bião-Lima, V, Cardoso, L, Camargos, PA, Chatkin, JM, Costa, RS, Coelho, ACC, Cooper, PJ, Cruz, AA, Cruz, CS, Cunha, J, de Jesus, JV, Fernandes, J, Franco, RA, Gomes-Filho, I, Lima-Matos, A, Figueiredo, CA, Lessa, MA, Lins, L, Mello, LM, Moura-Santos, P, Muniz, IS, Paixao-Araujo, I, Pinheiro, GP, Ponte, EV, Rodrigues, LC, Santana, CVN, Santos-Lima, G, Souza, TMO, Souza-Machado, A, Souza-Machado, C & GUO, Y-K 2020, 'Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status', Respiratory Medicine, vol. 161, 105817. https://doi.org/10.1016/j.rmed.2019.105817

TY - JOUR

T1 - Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

AU - Cruz, Alvaro A.

AU - Riley, John H.

AU - Bansal, Aruna T.

AU - Ponte, Eduardo V.

AU - Souza-Machado, Adelmir

AU - Almeida, Paula C.A.

AU - Biao-Lima, Valmar

AU - Davis, Maggie

AU - Bates, Stewart

AU - Adcock, Ian M.

AU - Sterk, Peter J.

AU - Chung, Kian Fan

AU - ProAR Study Group

AU - U-BIOPRED Study Groups

AU - Alcantara-Neves, N.

AU - Almeida, P. C.A.

AU - Amorim, L.

AU - Araujo, M. I.

AU - Barnes, K. C.

AU - Barreto, M. L.

AU - Belitardo, E.

AU - Bião-Lima, V.

AU - Cardoso, L.

AU - Camargos, P. A.

AU - Chatkin, J. M.

AU - Costa, R. S.

AU - Coelho, A. C.C.

AU - Cooper, P. J.

AU - Cruz, A. A.

AU - Cruz, C. S.

AU - Cunha, J.

AU - de Jesus, J. V.

AU - Fernandes, J.

AU - Franco, R. A.

AU - Gomes-Filho, I.

AU - Lima-Matos, A.

AU - Figueiredo, C. A.

AU - Lessa, M. A.

AU - Lins, L.

AU - Mello, L. M.

AU - Moura-Santos, P.

AU - Muniz, I. S.

AU - Paixao-Araujo, I.

AU - Pinheiro, G. P.

AU - Ponte, E. V.

AU - Rodrigues, L. C.

AU - Santana, C. V.N.

AU - Santos-Lima, G.

AU - Souza, T. M.O.

AU - Souza-Machado, A.

AU - Souza-Machado, C.

AU - GUO, Yi-Ke

N1 - Funding Information: For ProAR - Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq) – Grant # 471057/2014-2 , Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) and GlaxoSmilthKline investigator initiated grant. For U-BIOPRED - IMI EU funded project (no. 115010 ). Funding Information: For ProAR - Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico do Brasil (CNPq) ? Grant # 471057/2014-2, Funda??o de Amparo a Pesquisa do Estado da Bahia (FAPESB) and GlaxoSmilthKline investigator initiated grant. For U-BIOPRED - IMI EU funded project (no. 115010).

PY - 2020/1

Y1 - 2020/1

N2 - Background: Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

AB - Background: Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

KW - Asthma

KW - Biomarkers

KW - Cohort studies

KW - Cross sectional study

KW - Disease management

KW - Phenotypes

UR - http://www.scopus.com/inward/record.url?scp=85075530257&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2019.105817

DO - 10.1016/j.rmed.2019.105817

M3 - Journal article

C2 - 31790928

AN - SCOPUS:85075530257

SN - 0954-6111

VL - 161

JO - Respiratory Medicine

JF - Respiratory Medicine

M1 - 105817

ER -

Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

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