TY - JOUR
T1 - Associations of trimester-specific exposure to bisphenols with size at birth
T2 - A Chinese prenatal cohort study
AU - Hu, Jie
AU - Zhao, Hongzhi
AU - Braun, Joseph M.
AU - Zheng, Tongzhang
AU - Zhang, Bin
AU - Xia, Wei
AU - Zhang, Wenxin
AU - Li, Jiufeng
AU - Zhou, Yanqiu
AU - Li, Han
AU - Li, Jun
AU - Zhou, Aifen
AU - Zhang, Yiming
AU - Buka, Stephen L.
AU - Liu, Simin
AU - Peng, Yang
AU - Wu, Chuansha
AU - Jiang, Minmin
AU - Huo, Wenqian
AU - Zhu, Yingshuang
AU - Shi, Kunchong
AU - Li, Yuanyuan
AU - Cai, Zongwei
AU - Xu, Shunqing
N1 - Funding Information:
We thank all the staff and students who made contributions to the cohort study. We thank all the study participants for their support. This work was supported by the National Natural Science Foundation of China (91643207, 81903331, 91743101, and 21437002), the National Key Research and Development Plan of China (2016YFC0206203 and 2016YFC0206700), the Fundamental Research Funds for the Central Universities, Huazhong University of Science and Technology (HUST; 2015ZDTD047, 2016YXZD043, and 2018KFYXMPT00), Program for HUST Academic Frontier Youth Team (2018QYTD12, 2018QYTD06), the National Institute of Environmental Health Sciences (R01 ES024381), and the General Research Fund (12319716) from the Research Grants Council of Hong Kong.
PY - 2019/10
Y1 - 2019/10
N2 - Background: Bisphenol A (BPA) is an endocrine disruptor that affects fetal growth in experimental studies. Bisphenol F (BPF) and bisphenol S (BPS), which have been substituted for BPA in some consumer products, have also shown endocrine-disrupting effects in experimental models. However, the effects of BPF and BPS on fetal growth in humans are unknown. Objectives: Our goal was to investigate trimester-specific associations of urinary concentrations of BPA, BPF, and BPS with size at birth. Methods: The present study included 845 pregnant women from Wuhan, China (2013-2015), who provided one urine sample in each of the first, second, and third trimesters. Linear regressions with generalized estimating equations were applied to estimate trimester-specific associations of urinary bisphenol concentrations with birth weight, birth length, and ponderal index. Linear mixed-effects models were used to identify potential critical windows of susceptibility to bisphenols by comparing the exposure patterns of newborns in the 10th percentile of each birth anthropometric measurement to that of those in the 90th percentile. Results: Medians (25th-75th percentiles) of urinary concentrations of BPA, BPF, and BPS were 1.40 (0.19-3.85), 0.65 (0.34-1.39), and 0.38 (0.131.11) ng/mL, respectively. Urinary BPA concentrations in different trimesters were inversely, but not significantly, associated with birth weight and ponderal index. Urinary concentrations of BPF and BPS during some trimesters were associated with significantly lower birth weight, birth length, or ponderal index, with significant trend p-values (ptrend < 0.05) across quartiles of BPF and BPS concentrations. The observed associations were unchanged after additionally adjusting for other bisphenols. In addition, newborns in the 10th percentile of each birth anthropometry measure had higher BPF and BPS exposures during pregnancy than newborns in the 90th percentile of each outcome. Conclusions: Prenatal exposure to BPF and BPS was inversely associated with size at birth in this cohort. Replication in other populations is needed.
AB - Background: Bisphenol A (BPA) is an endocrine disruptor that affects fetal growth in experimental studies. Bisphenol F (BPF) and bisphenol S (BPS), which have been substituted for BPA in some consumer products, have also shown endocrine-disrupting effects in experimental models. However, the effects of BPF and BPS on fetal growth in humans are unknown. Objectives: Our goal was to investigate trimester-specific associations of urinary concentrations of BPA, BPF, and BPS with size at birth. Methods: The present study included 845 pregnant women from Wuhan, China (2013-2015), who provided one urine sample in each of the first, second, and third trimesters. Linear regressions with generalized estimating equations were applied to estimate trimester-specific associations of urinary bisphenol concentrations with birth weight, birth length, and ponderal index. Linear mixed-effects models were used to identify potential critical windows of susceptibility to bisphenols by comparing the exposure patterns of newborns in the 10th percentile of each birth anthropometric measurement to that of those in the 90th percentile. Results: Medians (25th-75th percentiles) of urinary concentrations of BPA, BPF, and BPS were 1.40 (0.19-3.85), 0.65 (0.34-1.39), and 0.38 (0.131.11) ng/mL, respectively. Urinary BPA concentrations in different trimesters were inversely, but not significantly, associated with birth weight and ponderal index. Urinary concentrations of BPF and BPS during some trimesters were associated with significantly lower birth weight, birth length, or ponderal index, with significant trend p-values (ptrend < 0.05) across quartiles of BPF and BPS concentrations. The observed associations were unchanged after additionally adjusting for other bisphenols. In addition, newborns in the 10th percentile of each birth anthropometry measure had higher BPF and BPS exposures during pregnancy than newborns in the 90th percentile of each outcome. Conclusions: Prenatal exposure to BPF and BPS was inversely associated with size at birth in this cohort. Replication in other populations is needed.
UR - http://www.scopus.com/inward/record.url?scp=85072847751&partnerID=8YFLogxK
U2 - 10.1289/EHP4664
DO - 10.1289/EHP4664
M3 - Journal article
C2 - 31573832
AN - SCOPUS:85072847751
SN - 0091-6765
VL - 127
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 10
M1 - 107001
ER -
