TY - JOUR
T1 - Associations between exposure to ambient particulate matter and advanced liver fibrosis in Chinese MAFLD patients
AU - Xing, Yunfei
AU - Gao, Xiangyang
AU - Li, Qin
AU - Li, Xueying
AU - Wang, Youxin
AU - Yang, Yifan
AU - Yang, Shuhan
AU - Lau, Patrick W.C.
AU - Zeng, Qiang
AU - Wang, Hui
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (82271770) and the Cyrus Tang Foundation for Young Scholars 2022 (2022-B126).
Publisher Copyright:
© 2023 Elsevier B.V. All rights reserved.
PY - 2023/10/15
Y1 - 2023/10/15
N2 - Background & Aims: Liver fibrosis is an important feature in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). This study aimed to explore the association between long-term ambient particulate matter (PM) exposure and advanced liver fibrosis (ALF) in MAFLD participants.Methods: A cross-sectional study of 23170 adults recruited from 33 provinces of China from 2010 to 2020. ALF was detected using the nonalcoholic fatty liver disease fibrosis score (NFS). The annual average levels of particulate matter with aerodynamic diameters of ≤ 1 µm (PM1), ≤ 2.5 µm (PM2.5) and ≤ 10 µm (PM10) were calculated using validated spatiotemporal models. Generalized additive models were applied to analyze the association between PM and ALF in patients with MAFLD.Results: One-year exposure to higher levels of all PM was found to increase the risk of ALF, with odds ratios (ORs) of 1.10 (95% CI 1.06–1.14), 1.05 (1.03–1.07), and 1.03(1.02–1.04) for each 10 μg/m3 increase in PM1, PM2.5 and PM10, respectively. With the dissection of the impact of PM1 in PM2.5, PM2.5 in PM10 and PM1 in PM10, we found that PM2.5 had a stronger impact on ALF (both Pinteraction<0.05) in comparison with PM1 and PM10.Conclusions: Long-term exposure to PM is associated with ALF in patients with MAFLD, with PM2.5 playing a dominant role.
AB - Background & Aims: Liver fibrosis is an important feature in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). This study aimed to explore the association between long-term ambient particulate matter (PM) exposure and advanced liver fibrosis (ALF) in MAFLD participants.Methods: A cross-sectional study of 23170 adults recruited from 33 provinces of China from 2010 to 2020. ALF was detected using the nonalcoholic fatty liver disease fibrosis score (NFS). The annual average levels of particulate matter with aerodynamic diameters of ≤ 1 µm (PM1), ≤ 2.5 µm (PM2.5) and ≤ 10 µm (PM10) were calculated using validated spatiotemporal models. Generalized additive models were applied to analyze the association between PM and ALF in patients with MAFLD.Results: One-year exposure to higher levels of all PM was found to increase the risk of ALF, with odds ratios (ORs) of 1.10 (95% CI 1.06–1.14), 1.05 (1.03–1.07), and 1.03(1.02–1.04) for each 10 μg/m3 increase in PM1, PM2.5 and PM10, respectively. With the dissection of the impact of PM1 in PM2.5, PM2.5 in PM10 and PM1 in PM10, we found that PM2.5 had a stronger impact on ALF (both Pinteraction<0.05) in comparison with PM1 and PM10.Conclusions: Long-term exposure to PM is associated with ALF in patients with MAFLD, with PM2.5 playing a dominant role.
KW - Advanced liver fibrosis
KW - Ambient particulate matter
KW - MAFLD
KW - NAFLD fibrosis score
UR - http://www.scopus.com/inward/record.url?scp=85170288099&partnerID=8YFLogxK
U2 - 10.1016/j.jhazmat.2023.132501
DO - 10.1016/j.jhazmat.2023.132501
M3 - Journal article
C2 - 37690203
AN - SCOPUS:85170288099
SN - 0304-3894
VL - 460
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 132501
ER -