TY - JOUR
T1 - Association of prenatal exposure to organochlorine pesticides and birth size
AU - Fang, Jing
AU - Liu, Hongxiu
AU - Zhao, Hongzhi
AU - WONG, Ming Hung
AU - Xu, Shunqing
AU - CAI, Zongwei
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China (Grant numbers 21437002 ), General Research Fund ( GRF 12304117 ), and Collaborative Research Fund (CRF) C2014-14E from Research Grants Council (RGC) of Hong Kong, China.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - There has been substantial evidence showing the adverse effects of organochlorine pesticide (OCP) exposure on human, but studies focused on the prenatal exposure effects at low OCP levels on infant birth size were scarce and controversial. In this study, cord serum samples were collected at the delivery from 1028 pairs of mothers and newborns in Wuhan, China and investigated the associations of prenatal exposure to OCPs and birth size. The prenatal exposure of hexachlorocyclohexane isomers (HCHs), p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT) and its metabolites were analyzed. The associations between birth size and prenatal OCP exposure were examined by multiple linear regressions. A sex-specific relationship between the OCP exposure and birth size was observed. β-HCH was negatively associated with birth weight and ponderal index for boys [adjusted β = −28.61; 95% confidence interval (CI): −54.84, −4.37 and adjusted β = −0.17; 95% CI: −0.32, −0.01, respectively], whilst no significant associations with prenatal exposure of OCPs were found among girls. The inverse association of prenatal exposure to low levels of β-HCH was shown sex-specific difference, which was only observed significantly in boys. The findings strengthened the evidence that the fetal development was influenced by prenatal exposure to certain OCPs and the effects might be different in the newborn sex.
AB - There has been substantial evidence showing the adverse effects of organochlorine pesticide (OCP) exposure on human, but studies focused on the prenatal exposure effects at low OCP levels on infant birth size were scarce and controversial. In this study, cord serum samples were collected at the delivery from 1028 pairs of mothers and newborns in Wuhan, China and investigated the associations of prenatal exposure to OCPs and birth size. The prenatal exposure of hexachlorocyclohexane isomers (HCHs), p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT) and its metabolites were analyzed. The associations between birth size and prenatal OCP exposure were examined by multiple linear regressions. A sex-specific relationship between the OCP exposure and birth size was observed. β-HCH was negatively associated with birth weight and ponderal index for boys [adjusted β = −28.61; 95% confidence interval (CI): −54.84, −4.37 and adjusted β = −0.17; 95% CI: −0.32, −0.01, respectively], whilst no significant associations with prenatal exposure of OCPs were found among girls. The inverse association of prenatal exposure to low levels of β-HCH was shown sex-specific difference, which was only observed significantly in boys. The findings strengthened the evidence that the fetal development was influenced by prenatal exposure to certain OCPs and the effects might be different in the newborn sex.
KW - Birth size
KW - Cord serum
KW - Organochlorines pesticides
UR - http://www.scopus.com/inward/record.url?scp=85056564799&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2018.10.384
DO - 10.1016/j.scitotenv.2018.10.384
M3 - Journal article
C2 - 30448658
AN - SCOPUS:85056564799
SN - 0048-9697
VL - 654
SP - 678
EP - 683
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -