TY - JOUR
T1 - Association of in utero hexachlorocyclohexane exposure with gestational age
AU - Fang, Jing
AU - Liu, Hongxiu
AU - Zhao, Hongzhi
AU - Zhou, Yanqiu
AU - Xu, Shunqing
AU - CAI, Zongwei
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China (Grant no. 21437002 ), General Research Fund ( GRF12319716 ), and Collaborative Research Fund (CRF) C2014-14E from Research Grants Council (RGC) of Hong Kong, China.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - As endocrine disrupting chemicals, hexachlorocyclohexane (HCH) isomers were reported to impair the intrauterine growth. Although the findings of HCHs with preterm birth were well established, the associations with gestational age were limited. In the present study, we examined whether exposure to HCHs would influence gestational age. The study population included 1028 pregnant women and their offspring who were born in 2014–2015 from a birth cohort in Wuhan, China. Associations of the cord serum HCH levels with gestational age were estimated using generalized linear models. We found higher HCH levels in pregnant women, who were elder, had higher body mass index (BMI) before pregnancy, received higher education, or were exposed to smoking passively. For term birth, the 3rd tertiles of α-HCH and γ-HCH were significantly associated with shorter gestational age [crude β = −1.017, confidence interval (CI): − 2.017, − 0.018 for α-HCH, crude β = −1.068, CI: − 2.067, − 0.070 for γ-HCH], and relationships were similar after adjusted by covariates. Stratified analysis showed positive associations between α-HCH and gestational age for mothers younger than 25 years old (adjusted β = 0.610, CI: 0.061, 1.158), while showing negative relationships for mothers elder than 35 years old (adjusted β = −1.365, CI: −2.414, −0.317). In summary, our results indicated cord serum levels of HCHs were associated with gestational age at birth.
AB - As endocrine disrupting chemicals, hexachlorocyclohexane (HCH) isomers were reported to impair the intrauterine growth. Although the findings of HCHs with preterm birth were well established, the associations with gestational age were limited. In the present study, we examined whether exposure to HCHs would influence gestational age. The study population included 1028 pregnant women and their offspring who were born in 2014–2015 from a birth cohort in Wuhan, China. Associations of the cord serum HCH levels with gestational age were estimated using generalized linear models. We found higher HCH levels in pregnant women, who were elder, had higher body mass index (BMI) before pregnancy, received higher education, or were exposed to smoking passively. For term birth, the 3rd tertiles of α-HCH and γ-HCH were significantly associated with shorter gestational age [crude β = −1.017, confidence interval (CI): − 2.017, − 0.018 for α-HCH, crude β = −1.068, CI: − 2.067, − 0.070 for γ-HCH], and relationships were similar after adjusted by covariates. Stratified analysis showed positive associations between α-HCH and gestational age for mothers younger than 25 years old (adjusted β = 0.610, CI: 0.061, 1.158), while showing negative relationships for mothers elder than 35 years old (adjusted β = −1.365, CI: −2.414, −0.317). In summary, our results indicated cord serum levels of HCHs were associated with gestational age at birth.
KW - Cord serum
KW - Gestational age
KW - Hexachlorocyclohexane
UR - http://www.scopus.com/inward/record.url?scp=85062238507&partnerID=8YFLogxK
U2 - 10.1016/j.ecoenv.2019.02.089
DO - 10.1016/j.ecoenv.2019.02.089
M3 - Journal article
C2 - 30831475
AN - SCOPUS:85062238507
SN - 0147-6513
VL - 174
SP - 263
EP - 269
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
ER -