Association between Pre-Diagnostic Serum Bile Acids and Hepatocellular Carcinoma: The Singapore Chinese Health Study

Claire E. Thomas, Hung N. Luu, Renwei Wang, Guoxiang Xie, Jennifer Adams-Haduch, Aizhen Jin, Woon Puay Koh, Wei Jia, Jaideep Behari, Jian Min Yuan*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

30 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis. The increasing incidence rate of HCC in developed countries has been linked to increasing prevalence of metabolic dysfunction-associated fatty liver disease, which has characteristics of altered bile acid metabolism that may predate hepatocarcinogenesis. The aim of the present study was to assess the association of circulating bile acid levels in pre-diagnostic serum with the risk of developing HCC in a general population in Singapore. Primary conjugated bile acids were most strongly associated with increased risk of HCC whereas the ratios of secondary over primary bile acids were significantly associated with reduced risk. These results support a contributing role of dysmetabolism of bile acids in the development of HCC. The modulation of bile acid metabolism through alteration of gut microbiota may be an effective strategy for primary prevention against HCC in individuals with metabolic dysfunction-associated fatty liver disease.

Original languageEnglish
Article number2648
Number of pages15
JournalCancers
Volume13
Issue number11
DOIs
Publication statusPublished - 1 Jun 2021
Externally publishedYes

Scopus Subject Areas

  • Oncology
  • Cancer Research

User-Defined Keywords

  • Hepatocellular carcinoma
  • Liver
  • Metabolism
  • Molecular epidemiology
  • Serum bile acids

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