TY - JOUR
T1 - Assessment of risk of PCDD/Fs and dioxin-like PCBs in marine and freshwater fish in Pearl River Delta, China
AU - WEI, Xi
AU - LEUNG, Kelvin S Y
AU - WONG, Ming Hung
AU - Giesy, J.
AU - CAI, Zongwei
AU - WONG, Chris K C
N1 - Funding Information:
This work was supported by the Super Faculty Research Grant, Hong Kong Baptist University and Collaborative Research Fund ( HKBU 1/CRF/08 ), University Grants Committee (to Prof. C.K.C. Wong). Dioxin analysis was conducted by Dioxin Analysis Laboratory, supervised by Prof. Z.W. Cai, Department of Chemistry, Hong Kong Baptist University. Prof. Giesy was supported by the Canada Research Chair program and an at large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong.
PY - 2011
Y1 - 2011
N2 - Fish consumption is known to be beneficial to human health. However since the age of industrialization, the released/disposed chemical pollutants into water systems make fish a source of various environmental toxicants to humans. In oceanic cities with heavy industrial activities, fish products contribute the greatest proportion of exposure to pollutants. In this study, risks and potential effects of dioxins to health of coastal populations in the Pearl River Delta were assessed. Concentrations of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) were measured in common fish species purchased at local markets. Concentrations of total dioxins in fish ranged from 0.481 to 9.05. pg TEQ/g wet weight were similar to the lesser concentrations reported for fish from other countries. The greatest concentrations of dioxins were measured in mandarin fish, a carnivorous freshwater fish. Exposure of murine primary leydig and ovarian cells to 2,3,7,8-tetrachlorinated dibenzo- p-dioxins (2,3,7,8-TCDD) reduced the synthesis of progesterone, testosterone and/or estrogen. The reductions were probably via inhibitory effects on the expression of the steroidogenic enzymes, steroidogenic acute regulatory protein (StAR) and cytochrome P450 side-chain cleavage enzyme (P450scc). Based on these reproductive parameters, the concentrations of dioxins and dioxin-like residues represent a moderate health risk due to consumption of fish.
AB - Fish consumption is known to be beneficial to human health. However since the age of industrialization, the released/disposed chemical pollutants into water systems make fish a source of various environmental toxicants to humans. In oceanic cities with heavy industrial activities, fish products contribute the greatest proportion of exposure to pollutants. In this study, risks and potential effects of dioxins to health of coastal populations in the Pearl River Delta were assessed. Concentrations of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) were measured in common fish species purchased at local markets. Concentrations of total dioxins in fish ranged from 0.481 to 9.05. pg TEQ/g wet weight were similar to the lesser concentrations reported for fish from other countries. The greatest concentrations of dioxins were measured in mandarin fish, a carnivorous freshwater fish. Exposure of murine primary leydig and ovarian cells to 2,3,7,8-tetrachlorinated dibenzo- p-dioxins (2,3,7,8-TCDD) reduced the synthesis of progesterone, testosterone and/or estrogen. The reductions were probably via inhibitory effects on the expression of the steroidogenic enzymes, steroidogenic acute regulatory protein (StAR) and cytochrome P450 side-chain cleavage enzyme (P450scc). Based on these reproductive parameters, the concentrations of dioxins and dioxin-like residues represent a moderate health risk due to consumption of fish.
KW - Fish
KW - Leydig cells
KW - Ovarian cells
KW - Polychlorinated dibenzo-p-dioxins
KW - Polychlorinated dibenzofurans
UR - http://www.scopus.com/inward/record.url?scp=79960341744&partnerID=8YFLogxK
U2 - 10.1016/j.marpolbul.2011.02.025
DO - 10.1016/j.marpolbul.2011.02.025
M3 - Journal article
C2 - 21392810
AN - SCOPUS:79960341744
SN - 0025-326X
VL - 63
SP - 166
EP - 171
JO - Marine Pollution Bulletin
JF - Marine Pollution Bulletin
IS - 5-12
ER -
