Assessing the Impact of PM2.5-Bound Arsenic on Cardiovascular Risk among Workers in a Non-ferrous Metal Smelting Area: Insights from Chemical Speciation and Bioavailability

Zenghua Qi, Qiting Zhao, Zixun Yu, Zhu Yang, Jie Feng, Pengfei Song, Xiaochong He, Xingwen Lu, Xin Chen, Shoupeng Li, Yong Yuan, Zongwei Cai*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

Inhalation of fine particulate matter PM2.5-bound arsenic (PM2.5-As) may cause significant cardiovascular damage, due to its high concentration, long transmission range, and good absorption efficiency in organisms. However, both the contribution and the effect of the arsenic exposure pathway, with PM2.5 as the medium, on cardiovascular system damage in nonferrous smelting sites remain to be studied. In this work, a one-year site sample collection and analysis work showed that the annual concentration of PM2.5-As reached 0.74 μg/m3, which was 120 times the national standard. The predominant species in the PM2.5 samples were As (V) and As (III). A panel study among workers revealed that PM2.5-As exposure dominantly contributed to human absorption of As. After exposure of mice to PM2.5-As for 8 weeks, the accumulation of As in the high exposure group reached equilibrium, and its bioavailability was 24.5%. A series of animal experiments revealed that PM2.5-As exposure induced cardiac injury and dysfunction at the environmental relevant concentration and speciation. By integrating environmental and animal exposure assessments, more accurate health risk assessment models exposed to PM2.5-As were established for metal smelting areas. Therefore, our research provides an important scientific basis for relevant departments to formulate industry supervision, prevention and control policies.
Original languageEnglish
Pages (from-to)8228–8238
Number of pages11
JournalEnvironmental Science and Technology
Volume58
Issue number19
Early online date2 May 2024
DOIs
Publication statusPublished - 14 May 2024

Scopus Subject Areas

  • Chemistry(all)
  • Environmental Chemistry

User-Defined Keywords

  • Bioavailability
  • Health risk assessment
  • Heart dysfunction
  • PM2.5-As Chemical speciation
  • Chemical speciation
  • PM2.5-As

Fingerprint

Dive into the research topics of 'Assessing the Impact of PM2.5-Bound Arsenic on Cardiovascular Risk among Workers in a Non-ferrous Metal Smelting Area: Insights from Chemical Speciation and Bioavailability'. Together they form a unique fingerprint.

Cite this