Arabidopsis Yak1 protein (AtYak1) is a dual specificity protein kinase

Dongjin Kim*, Valentine Otang Ntui, Nianshu Zhang, Liming Xiong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

12 Citations (Scopus)


Yak1 is a member of dual-specificity Tyr phosphorylation-regulated kinases (DYRKs) that are evolutionarily conserved. The downstream targets of Yak1 and their functions are largely unknown. Here, a homologous protein AtYAK1 was identified inArabidopsis thaliana and the phosphoprotein profiles of the wild type and anatyak1 mutant were compared on two-dimensional gel following Pro-Q Diamond phosphoprotein gel staining. Annexin1, Annexin2 and RBD were phosphorylated at serine/threonine residues by the AtYak1 kinase. Annexin1, Annexin2 and Annexin4 were also phosphorylated at tyrosine residues. Our study demonstrated that AtYak1 is a dual specificity protein kinase in Arabidopsis that may regulate the phosphorylation status of the annexin family proteins.

Original languageEnglish
Pages (from-to)3321-3327
Number of pages7
JournalFEBS Letters
Issue number21
Publication statusPublished - 24 Oct 2015

Scopus Subject Areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

User-Defined Keywords

  • Dual specificity protein kinase
  • Phosphopeptide
  • Phosphorylation
  • Serine/threonine protein kinase
  • Tyrosine protein kinase


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