TY - JOUR
T1 - Aqueous Circularly Polarized Luminescence Induced by Homopolypeptide Self-Assembly
AU - Jiang, Jinhui
AU - Ma, Fulong
AU - Dong, Ruihua
AU - Zhang, Siwei
AU - Zhang, Zicong
AU - Tan, Haozhe
AU - Cai, Xumin
AU - Qiu, Zijie
AU - Xiong, Yu
AU - Han, Wei
AU - Zhao, Zheng
AU - Tang, Ben Zhong
N1 - Funding information:
The authors gratefully acknowledge financial support from the National Natural Science Foundation of China (52003228, 52273197, and 52333007), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), the Science and Technology Plan of Shenzhen (JCYJ2021324134613038, KQTD20210811090142053, JSGG20220606141800001, GJHZ20210705141810031), National Science Foundation of China (Grant No. 21977011 to W.H.), and the Shenzhen Fundamental Research Program (Grant No. GXWD20201231165807007-20200827170132001 to W.H.). The authors thank the AIE Institute (www.aietech.org.cn) for providing some technical assistance.
Publisher copyright:
© 2023 American Chemical Society
PY - 2023/12/20
Y1 - 2023/12/20
N2 - Remarkable advances have been achieved in solution self-assembly of polypeptides from the perspective of nanostructures, mechanisms, and applications. Despite the intrinsic chirality of polypeptides, the promising generation of aqueous circularly polarized luminescence (CPL) based on their self-assembly has been rarely reported due to the weak fluorescence of most polypeptides and the indeterminate self-assembly mechanism. Here, we propose a facile strategy for achieving aqueous CPL based on the self-assembly of simple homopolypeptides modified with a terminal group featuring both twisted intramolecular charge transfer and aggregation-induced emission properties. A morphology-dependent CPL can be observed under different self-assembly conditions by altering the solvents. A nanotoroid-dispersed aqueous solution with detectable CPL can be obtained by using tetrahydrofuran as a good solvent for the self-assembly, which is attributed to the involvement of the terminal group in the chiral environment formed by the homopolypeptide chains. However, such a chiral packing mode cannot be realized in nanorods self-assembled from dioxane, resulting in an inactive CPL phenomenon. Furthermore, CPL signals can be greatly amplified by co-assembly of homopolypeptides with the achiral small molecule derived from the terminal group. This work not only provides a pathway to construct aqueous CPL-active homopolypeptide nanomaterials but also reveals a potential mechanism in the self-assembly for chiral production, transfer, and amplification in polypeptide-based nanostructures.
AB - Remarkable advances have been achieved in solution self-assembly of polypeptides from the perspective of nanostructures, mechanisms, and applications. Despite the intrinsic chirality of polypeptides, the promising generation of aqueous circularly polarized luminescence (CPL) based on their self-assembly has been rarely reported due to the weak fluorescence of most polypeptides and the indeterminate self-assembly mechanism. Here, we propose a facile strategy for achieving aqueous CPL based on the self-assembly of simple homopolypeptides modified with a terminal group featuring both twisted intramolecular charge transfer and aggregation-induced emission properties. A morphology-dependent CPL can be observed under different self-assembly conditions by altering the solvents. A nanotoroid-dispersed aqueous solution with detectable CPL can be obtained by using tetrahydrofuran as a good solvent for the self-assembly, which is attributed to the involvement of the terminal group in the chiral environment formed by the homopolypeptide chains. However, such a chiral packing mode cannot be realized in nanorods self-assembled from dioxane, resulting in an inactive CPL phenomenon. Furthermore, CPL signals can be greatly amplified by co-assembly of homopolypeptides with the achiral small molecule derived from the terminal group. This work not only provides a pathway to construct aqueous CPL-active homopolypeptide nanomaterials but also reveals a potential mechanism in the self-assembly for chiral production, transfer, and amplification in polypeptide-based nanostructures.
UR - http://www.scopus.com/inward/record.url?scp=85180084618&partnerID=8YFLogxK
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001128300600001?SID=EUW1ED0A3CLm3p1PpB21wdj0uAjzI
U2 - 10.1021/jacs.3c06769
DO - 10.1021/jacs.3c06769
M3 - Journal article
C2 - 38063341
SN - 0002-7863
VL - 145
SP - 27282
EP - 27294
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 50
ER -