Aptamer-assembled nanomaterials for fluorescent sensing and imaging

Danqing Lu, Lei He, Ge ZHANG, Aiping LYU, Ruowen Wang, Xiaobing Zhang, Weihong Tan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

43 Citations (Scopus)


Aptamers, which are selected in vitro by a technology known as the systematic evolution of ligands by exponential enrichment (SELEX), represent a crucial recognition element in molecular sensing. With advantages such as good biocompatibility, facile functionalization, and special optical and physical properties, various nanomaterials can protect aptamers from enzymatic degradation and nonspecific binding in living systems and thus provide a preeminent platform for biochemical applications. Coupling aptamers with various nanomaterials offers many opportunities for developing highly sensitive and selective sensing systems. Here, we focus on the recent applications of aptamer-assembled nanomaterials in fluorescent sensing and imaging. Different types of nanomaterials are examined along with their advantages and disadvantages. Finally, we look toward the future of aptamer-assembled nanomaterials.

Original languageEnglish
Pages (from-to)109-121
Number of pages13
Issue number1
Publication statusPublished - 1 Jan 2017

Scopus Subject Areas

  • Biotechnology
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

User-Defined Keywords

  • aptamer
  • bioimaging
  • biosensing
  • cancer therapy
  • disease diagnosis
  • drug delivery
  • nanomaterials
  • self-assembly


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