Applying bioinformatic technique to discovery molecular mechansim of Banxia and Tianma combination treating tinnitus

Shanshan Shen, Yaoxian Wang, Guang Zheng, Xiaojuan He, Yong Tan, Ke Zhou, Dongmei Jia, Aiping LYU, Miao Jiang*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Tinnitus is the most common medical symptom that can be debilitating. Chinese herbal medicines (CHMs) play important roles in tinnitus treatment. This study analyzed the most frequently prescribed herbs used to treat tinnitus and the molecular mechanisms of therapeutic effects of these CHMs by text mining and bioinformatics technique. Results showed that pinellia ternate (Banxia) and gastrodin (Tianma) are the most frequently prescribed CHMs for treatment tinnitus. The molecular mechanisms of therapeutic effects of two CHMs were focused on sertoli cell-sertoli cell juntion signaling and NRF2-mediated oxidative stress response signaling. Integrative text mining and bioinformatics analysis may be a promising approach to find new drug and decipher their molecular mechanism intuitively.

Original languageEnglish
Title of host publicationProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
EditorsHuiru Zheng, Xiaohua Tony Hu, Yadong Wang, Jin-Kao Hao, David Gilbert, Daniel Berrar, Kwang-Hyun Cho, Werner Dubitzky
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages160-161
Number of pages2
ISBN (Electronic)9781479956692
DOIs
Publication statusPublished - 29 Dec 2014
Event2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 - Belfast, United Kingdom
Duration: 2 Nov 20145 Nov 2014

Publication series

NameProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

Conference

Conference2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Country/TerritoryUnited Kingdom
CityBelfast
Period2/11/145/11/14

Scopus Subject Areas

  • Biomedical Engineering
  • Health Informatics

User-Defined Keywords

  • bioinformatic technique
  • gastrodin (Tianma)
  • pinellia ternate(Banxia)
  • tinnitus

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