@inproceedings{8371d0fbd31e4ad9a7cc8b5b12901509,
title = "Applying bioinformatic technique to discovery molecular mechansim of Banxia and Tianma combination treating tinnitus",
abstract = "Tinnitus is the most common medical symptom that can be debilitating. Chinese herbal medicines (CHMs) play important roles in tinnitus treatment. This study analyzed the most frequently prescribed herbs used to treat tinnitus and the molecular mechanisms of therapeutic effects of these CHMs by text mining and bioinformatics technique. Results showed that pinellia ternate (Banxia) and gastrodin (Tianma) are the most frequently prescribed CHMs for treatment tinnitus. The molecular mechanisms of therapeutic effects of two CHMs were focused on sertoli cell-sertoli cell juntion signaling and NRF2-mediated oxidative stress response signaling. Integrative text mining and bioinformatics analysis may be a promising approach to find new drug and decipher their molecular mechanism intuitively.",
keywords = "bioinformatic technique, gastrodin (Tianma), pinellia ternate(Banxia), tinnitus",
author = "Shanshan Shen and Yaoxian Wang and Guang Zheng and Xiaojuan He and Yong Tan and Ke Zhou and Dongmei Jia and Aiping LYU and Miao Jiang",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 ; Conference date: 02-11-2014 Through 05-11-2014",
year = "2014",
month = dec,
day = "29",
doi = "10.1109/BIBM.2014.6999348",
language = "English",
series = "Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014",
publisher = "IEEE",
pages = "160--161",
editor = "Zheng, {Huiru (Jane)} and Xiaohua Hu and Daniel Berrar and Yadong Wang and Werner Dubitzky and Jin-Kao Hao and Kwang-Hyun Cho and David Gilbert",
booktitle = "Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014",
address = "United States",
}