Application of temperature-correlated mobility theory for optimizing the MEKC separation of the main lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction

Jingyi Liu, Nickolaj Jacob Petersen*, Kai Fai Lee, Steen Honoré Hansen, Lixing Lao, Cho Wing Sze, Yanbo Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The present work shows the application of the temperature-correlated mobility theory for the optimization of the separation and peak alignment of the main lignans from water extracts of traditional Chinese medicine Schisandra Chinensis Fructus as well as its prescription Yuye Decoction (Jade Fluid Decoction; YYD). This is the first application of this theory for MEKC separations, and the data presentation allows a much easier peak tracking and thereby identification of the analytes. Most interestingly, the data obtained and presented in the mobility scale at 298 K, show that Schisantherin A, which is easily mistaken as one of the analytes using traditional time scale, was actually not detected in Schisandra Chinensis Fructus and Yuye Decoction (Jade Fluid Decoction) water extracts. This proves the value of the temperature-correlated mobility scale for method optimization of complex samples. Thus, in the temperature-correlated mobility scale, the optimization of the system conditions for the MEKC separations can easily be achieved by correcting for viscosity changes. Also, the influence of the operating temperature can be monitored in a more distinct way.
Original languageEnglish
Pages (from-to)2907-2914
Number of pages8
JournalElectrophoresis
Volume35
Issue number20
Early online date14 Jul 2014
DOIs
Publication statusPublished - Oct 2014

Scopus Subject Areas

  • Medicine(all)

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