Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis

Chung Hang Leung, Ke Jia Wu, Guodong Li, Chun Wu, Chung Nga Ko, Edmond Dik Lung MA*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Circulating tumor cells (CTCs) are an important biomarker for various types of cancers. As CTCs are extremely rare in the bloodstream, the accurate analysis and efficient separation of CTCs is a challenging task. In order to develop new diagnostic approaches for cancer research, understanding the functional characteristics of biomolecules at the single-molecule level in individual cancer cells is required. Meanwhile, microfluidic platforms have emerged as a promising technology for analyzing single molecules and single cells. In this review, we discuss some label-free techniques for biomolecule detection and highlight some reports that have employed combined label-free techniques with microfluidics for individual molecule or cancer cell analysis. Finally, we offer our perspective of the integration of label-free techniques with microfluidic technology on future applications.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalTrAC - Trends in Analytical Chemistry
Volume117
DOIs
Publication statusPublished - Aug 2019

Scopus Subject Areas

  • Analytical Chemistry
  • Spectroscopy

User-Defined Keywords

  • Circulating tumor cells
  • Label-free
  • Microfluidics
  • Nucleic-acid analysis
  • Protein analysis

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