Apoptosis and anti-cancer drug discovery: The power of medicinal fungi and plants

Jack Ho Wong; Stephen Cho Wing Sze; Tzi Bun Ng; Randy Chi Fai Cheung; Chit Tam; Kalin Yanbo Zhang; Xiuli Dan; Yau Sang Chan; William Chi Shing Cho; Charlene Cheuk Wing Ng; Mary Miu Yee Waye; Weicheng Liang; Jinfang Zhang; Jie Yang; Xiuyun Ye; Juan Lin; Xiujuan Ye; Hexiang Wang; Fang Liu; David Wai Chan; Hextan Yuen Sheung Ngan; Ou Sha; Guohui Li; Ryan Tse; Tak Fu Tse; Helen Chan

doi:10.2174/0929867324666170720165005

Apoptosis and anti-cancer drug discovery: The power of medicinal fungi and plants

Jack Ho Wong^*, Stephen Cho Wing Sze^*, Tzi Bun Ng^*, Randy Chi Fai Cheung, Chit Tam^*, Kalin Yanbo Zhang^*, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye^*, Hexiang Wang, Fang Liu, David Wai Chan^*Hextan Yuen Sheung Ngan^*, Ou Sha^*, Guohui Li, Ryan Tse, Tak Fu Tse^*, Helen Chan^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.

Original language	English
Pages (from-to)	5613-5630
Number of pages	18
Journal	Current Medicinal Chemistry
Volume	25
Issue number	40
DOIs	https://doi.org/10.2174/0929867324666170720165005
Publication status	Published - Dec 2018

Scopus Subject Areas

General Medicine

User-Defined Keywords

Medicinal fungi
medicinal plants
anticancer
apoptosis
mitochondria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2174/0929867324666170720165005

Cite this

Wong, J. H., Sze, S. C. W., Ng, T. B., Cheung, R. C. F., Tam, C., Zhang, K. Y., Dan, X., Chan, Y. S., Cho, W. C. S., Ng, C. C. W., Waye, M. M. Y., Liang, W., Zhang, J., Yang, J., Ye, X., Lin, J., Ye, X., Wang, H., Liu, F., ... Chan, H. (2018). Apoptosis and anti-cancer drug discovery: The power of medicinal fungi and plants. Current Medicinal Chemistry, 25(40), 5613-5630. https://doi.org/10.2174/0929867324666170720165005

@article{d1c7bf4bc2434ea49e0ff145bfb140e9,

title = "Apoptosis and anti-cancer drug discovery: The power of medicinal fungi and plants",

abstract = "The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.",

keywords = "Medicinal fungi, medicinal plants, anticancer, apoptosis, mitochondria",

author = "Wong, {Jack Ho} and Sze, {Stephen Cho Wing} and Ng, {Tzi Bun} and Cheung, {Randy Chi Fai} and Chit Tam and Zhang, {Kalin Yanbo} and Xiuli Dan and Chan, {Yau Sang} and Cho, {William Chi Shing} and Ng, {Charlene Cheuk Wing} and Waye, {Mary Miu Yee} and Weicheng Liang and Jinfang Zhang and Jie Yang and Xiuyun Ye and Juan Lin and Xiujuan Ye and Hexiang Wang and Fang Liu and Chan, {David Wai} and Ngan, {Hextan Yuen Sheung} and Ou Sha and Guohui Li and Ryan Tse and Tse, {Tak Fu} and Helen Chan",

note = "Funding information: The awards of HMRF grants (project number 12131221 and 13142271) from Food and Health Bureau, The Hong Kong Government and grants from National Natural Science Foundation of China (project number 81201270 and 81471927) are gratefully acknowledged. Publisher copyright: {\textcopyright} 2018 Bentham Science Publishers Ltd.",

year = "2018",

month = dec,

doi = "10.2174/0929867324666170720165005",

language = "English",

volume = "25",

pages = "5613--5630",

journal = "Current Medicinal Chemistry",

issn = "0929-8673",

publisher = "Bentham Science Publishers B.V.",

number = "40",

}

Wong, JH, Sze, SCW, Ng, TB, Cheung, RCF, Tam, C, Zhang, KY, Dan, X, Chan, YS, Cho, WCS, Ng, CCW, Waye, MMY, Liang, W, Zhang, J, Yang, J, Ye, X, Lin, J, Ye, X, Wang, H, Liu, F, Chan, DW, Ngan, HYS, Sha, O, Li, G, Tse, R, Tse, TF & Chan, H 2018, 'Apoptosis and anti-cancer drug discovery: The power of medicinal fungi and plants', Current Medicinal Chemistry, vol. 25, no. 40, pp. 5613-5630. https://doi.org/10.2174/0929867324666170720165005

TY - JOUR

T1 - Apoptosis and anti-cancer drug discovery

T2 - The power of medicinal fungi and plants

AU - Wong, Jack Ho

AU - Sze, Stephen Cho Wing

AU - Ng, Tzi Bun

AU - Cheung, Randy Chi Fai

AU - Tam, Chit

AU - Zhang, Kalin Yanbo

AU - Dan, Xiuli

AU - Chan, Yau Sang

AU - Cho, William Chi Shing

AU - Ng, Charlene Cheuk Wing

AU - Waye, Mary Miu Yee

AU - Liang, Weicheng

AU - Zhang, Jinfang

AU - Yang, Jie

AU - Ye, Xiuyun

AU - Lin, Juan

AU - Ye, Xiujuan

AU - Wang, Hexiang

AU - Liu, Fang

AU - Chan, David Wai

AU - Ngan, Hextan Yuen Sheung

AU - Sha, Ou

AU - Li, Guohui

AU - Tse, Ryan

AU - Tse, Tak Fu

AU - Chan, Helen

N1 - Funding information: The awards of HMRF grants (project number 12131221 and 13142271) from Food and Health Bureau, The Hong Kong Government and grants from National Natural Science Foundation of China (project number 81201270 and 81471927) are gratefully acknowledged. Publisher copyright: © 2018 Bentham Science Publishers Ltd.

PY - 2018/12

Y1 - 2018/12

N2 - The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.

AB - The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.

KW - Medicinal fungi

KW - medicinal plants

KW - anticancer

KW - apoptosis

KW - mitochondria

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85054981881&partnerID=MN8TOARS

U2 - 10.2174/0929867324666170720165005

DO - 10.2174/0929867324666170720165005

M3 - Review article

SN - 0929-8673

VL - 25

SP - 5613

EP - 5630

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 40

ER -

Apoptosis and anti-cancer drug discovery: The power of medicinal fungi and plants

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this