Antitumor activity of diethynylfluorene derivatives of gold(I)

Chung Hin CHUI; Raymond Siu Ming Wong; Roberto Gambari; Gregory Yin Ming Cheng; Marcus Chun Wah Yuen; Kit Wah Chan; See Wai Tong; Fung Yi Lau; Paul Bo San Lai; Kim Hung Lam; Cheuk Lam HO; Chi Wai Kan; Kelvin S Y LEUNG; Wai Yeung WONG

doi:10.1016/j.bmc.2009.10.034

Antitumor activity of diethynylfluorene derivatives of gold(I)

Chung Hin CHUI, Raymond Siu Ming Wong, Roberto Gambari, Gregory Yin Ming Cheng, Marcus Chun Wah Yuen, Kit Wah Chan, See Wai Tong, Fung Yi Lau, Paul Bo San Lai, Kim Hung Lam, Cheuk Lam HO, Chi Wai Kan^*, Kelvin S Y LEUNG, Wai Yeung WONG

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.

Original language	English
Pages (from-to)	7872-7877
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	17
Issue number	23
DOIs	https://doi.org/10.1016/j.bmc.2009.10.034
Publication status	Published - 1 Dec 2009

Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

User-Defined Keywords

Alkynes
Fluorenes derivatives
Gold(I) complexes
Human carcinoma cells
Nude mice model
Reactive oxygen species

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10.1016/j.bmc.2009.10.034

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CHUI, Chung Hin ; Wong, Raymond Siu Ming ; Gambari, Roberto ; Cheng, Gregory Yin Ming ; Yuen, Marcus Chun Wah ; Chan, Kit Wah ; Tong, See Wai ; Lau, Fung Yi ; Lai, Paul Bo San ; Lam, Kim Hung ; HO, Cheuk Lam ; Kan, Chi Wai ; LEUNG, Kelvin S Y ; WONG, Wai Yeung. / Antitumor activity of diethynylfluorene derivatives of gold(I). In: Bioorganic and Medicinal Chemistry. 2009 ; Vol. 17, No. 23. pp. 7872-7877.

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title = "Antitumor activity of diethynylfluorene derivatives of gold(I)",

abstract = "A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.",

keywords = "Alkynes, Fluorenes derivatives, Gold(I) complexes, Human carcinoma cells, Nude mice model, Reactive oxygen species",

author = "CHUI, {Chung Hin} and Wong, {Raymond Siu Ming} and Roberto Gambari and Cheng, {Gregory Yin Ming} and Yuen, {Marcus Chun Wah} and Chan, {Kit Wah} and Tong, {See Wai} and Lau, {Fung Yi} and Lai, {Paul Bo San} and Lam, {Kim Hung} and HO, {Cheuk Lam} and Kan, {Chi Wai} and LEUNG, {Kelvin S Y} and WONG, {Wai Yeung}",

note = "Funding Information: The authors wish to acknowledge the financial support to this work from The Hong Kong Polytechnic University to C.-W. Kan (A-PD1G). W.-Y. Wong would like to acknowledge the Hong Kong Research Grants Council ( HKBU 202106 ) and Hong Kong Baptist University ( FRG/08-09/I-20 ) for financial support. C.-H. Chui is supported by the Assistant Professorship kindly offered by Prof. X.-M. Tao. R. Gambari is sponsored by AIRC (Italian Association for Cancer Research).",

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doi = "10.1016/j.bmc.2009.10.034",

language = "English",

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Antitumor activity of diethynylfluorene derivatives of gold(I). / CHUI, Chung Hin; Wong, Raymond Siu Ming; Gambari, Roberto; Cheng, Gregory Yin Ming; Yuen, Marcus Chun Wah; Chan, Kit Wah; Tong, See Wai; Lau, Fung Yi; Lai, Paul Bo San; Lam, Kim Hung; HO, Cheuk Lam; Kan, Chi Wai; LEUNG, Kelvin S Y; WONG, Wai Yeung.

In: Bioorganic and Medicinal Chemistry, Vol. 17, No. 23, 01.12.2009, p. 7872-7877.

Research output: Contribution to journal › Article › peer-review

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T1 - Antitumor activity of diethynylfluorene derivatives of gold(I)

AU - CHUI, Chung Hin

AU - Wong, Raymond Siu Ming

AU - Gambari, Roberto

AU - Cheng, Gregory Yin Ming

AU - Yuen, Marcus Chun Wah

AU - Chan, Kit Wah

AU - Tong, See Wai

AU - Lau, Fung Yi

AU - Lai, Paul Bo San

AU - Lam, Kim Hung

AU - HO, Cheuk Lam

AU - Kan, Chi Wai

AU - LEUNG, Kelvin S Y

AU - WONG, Wai Yeung

N1 - Funding Information: The authors wish to acknowledge the financial support to this work from The Hong Kong Polytechnic University to C.-W. Kan (A-PD1G). W.-Y. Wong would like to acknowledge the Hong Kong Research Grants Council ( HKBU 202106 ) and Hong Kong Baptist University ( FRG/08-09/I-20 ) for financial support. C.-H. Chui is supported by the Assistant Professorship kindly offered by Prof. X.-M. Tao. R. Gambari is sponsored by AIRC (Italian Association for Cancer Research).

PY - 2009/12/1

Y1 - 2009/12/1

N2 - A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.

AB - A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.

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KW - Fluorenes derivatives

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Antitumor activity of diethynylfluorene derivatives of gold(I)

Abstract

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