@article{ff3eda3d60c6465797be619a65d05dc5,
title = "Antitumor activity of diethynylfluorene derivatives of gold(I)",
abstract = "A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.",
keywords = "Alkynes, Fluorenes derivatives, Gold(I) complexes, Human carcinoma cells, Nude mice model, Reactive oxygen species",
author = "Chui, {Chung Hin} and Wong, {Raymond Siu Ming} and Roberto Gambari and Cheng, {Gregory Yin Ming} and Yuen, {Marcus Chun Wah} and Chan, {Kit Wah} and Tong, {See Wai} and Lau, {Fung Yi} and Lai, {Paul Bo San} and Lam, {Kim Hung} and Ho, {Cheuk Lam} and Kan, {Chi Wai} and Leung, {Kelvin Sze Yin} and Wong, {Wai Yeung}",
note = "Funding Information: The authors wish to acknowledge the financial support to this work from The Hong Kong Polytechnic University to C.-W. Kan (A-PD1G). W.-Y. Wong would like to acknowledge the Hong Kong Research Grants Council (HKBU 202106) and Hong Kong Baptist University (FRG/08-09/I-20) for financial support. C.-H. Chui is supported by the Assistant Professorship kindly offered by Prof. X.-M. Tao. R. Gambari is sponsored by AIRC (Italian Association for Cancer Research). Publisher copyright: {\textcopyright} 2009 Elsevier Ltd.",
year = "2009",
month = dec,
day = "1",
doi = "10.1016/j.bmc.2009.10.034",
language = "English",
volume = "17",
pages = "7872--7877",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd.",
number = "23",
}
