Antitumor activity of diethynylfluorene derivatives of gold(I)

Chung Hin CHUI, Raymond Siu Ming Wong, Roberto Gambari, Gregory Yin Ming Cheng, Marcus Chun Wah Yuen, Kit Wah Chan, See Wai Tong, Fung Yi Lau, Paul Bo San Lai, Kim Hung Lam, Cheuk Lam HO, Chi Wai Kan*, Kelvin S Y LEUNG, Wai Yeung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.

Original languageEnglish
Pages (from-to)7872-7877
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number23
DOIs
Publication statusPublished - 1 Dec 2009

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

User-Defined Keywords

  • Alkynes
  • Fluorenes derivatives
  • Gold(I) complexes
  • Human carcinoma cells
  • Nude mice model
  • Reactive oxygen species

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