Antituberculosis cycloartane triterpenoids from Radermachera boniana

Ngan B. Truong; Cuong V. Pham; Huong T.M. Doan; Hung V. Nguyen; Cuong M. Nguyen; Hiep T. Nguyen; Hong Jie Zhang; Harry H.S. Fong; Scott G. Franzblau; Djaja D. Soejarto; Minh V. Chau

doi:10.1021/np200022b

Antituberculosis cycloartane triterpenoids from Radermachera boniana

Ngan B. Truong, Cuong V. Pham^*, Huong T.M. Doan, Hung V. Nguyen, Cuong M. Nguyen, Hiep T. Nguyen, Hong Jie Zhang, Harry H.S. Fong, Scott G. Franzblau, Djaja D. Soejarto, Minh V. Chau^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H₃₇Rv strain. (Chemical Equation Presented).

Original language	English
Pages (from-to)	1318-1322
Number of pages	5
Journal	Journal of Natural Products
Volume	74
Issue number	5
Early online date	6 Apr 2011
DOIs	https://doi.org/10.1021/np200022b
Publication status	Published - 27 May 2011

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np200022b

Cite this

@article{0dd595a8f6524d6695ffb352961b2cd1,

title = "Antituberculosis cycloartane triterpenoids from Radermachera boniana",

abstract = "Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain. (Chemical Equation Presented).",

author = "Truong, {Ngan B.} and Pham, {Cuong V.} and Doan, {Huong T.M.} and Nguyen, {Hung V.} and Nguyen, {Cuong M.} and Nguyen, {Hiep T.} and Zhang, {Hong Jie} and Fong, {Harry H.S.} and Franzblau, {Scott G.} and Soejarto, {Djaja D.} and Chau, {Minh V.}",

year = "2011",

month = may,

day = "27",

doi = "10.1021/np200022b",

language = "English",

volume = "74",

pages = "1318--1322",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Antituberculosis cycloartane triterpenoids from Radermachera boniana

AU - Truong, Ngan B.

AU - Pham, Cuong V.

AU - Doan, Huong T.M.

AU - Nguyen, Hung V.

AU - Nguyen, Cuong M.

AU - Nguyen, Hiep T.

AU - Zhang, Hong Jie

AU - Fong, Harry H.S.

AU - Franzblau, Scott G.

AU - Soejarto, Djaja D.

AU - Chau, Minh V.

PY - 2011/5/27

Y1 - 2011/5/27

N2 - Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain. (Chemical Equation Presented).

AB - Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain. (Chemical Equation Presented).

UR - http://www.scopus.com/inward/record.url?scp=79957797853&partnerID=8YFLogxK

U2 - 10.1021/np200022b

DO - 10.1021/np200022b

M3 - Article

C2 - 21469696

AN - SCOPUS:79957797853

SN - 0163-3864

VL - 74

SP - 1318

EP - 1322

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Antituberculosis cycloartane triterpenoids from Radermachera boniana

Abstract

Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this