Antituberculosis cycloartane triterpenoids from Radermachera boniana

Ngan B. Truong; Cuong V. Pham; Huong T.M. Doan; Hung V. Nguyen; Cuong M. Nguyen; Hiep T. Nguyen; Hong Jie Zhang; Harry H.S. Fong; Scott G. Franzblau; Djaja D. Soejarto; Minh V. Chau

doi:10.1021/np200022b

Antituberculosis cycloartane triterpenoids from Radermachera boniana

Ngan B. Truong
, Cuong V. Pham^*
, Huong T.M. Doan
, Hung V. Nguyen
, Cuong M. Nguyen
, Hiep T. Nguyen
, Hong Jie Zhang
, Harry H.S. Fong
, Scott G. Franzblau
, Djaja D. Soejarto
, Minh V. Chau^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

42 Citations (Scopus)

Abstract

Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H₃₇Rv strain. (Chemical Equation Presented).

Original language	English
Pages (from-to)	1318-1322
Number of pages	5
Journal	Journal of Natural Products
Volume	74
Issue number	5
Early online date	6 Apr 2011
DOIs	https://doi.org/10.1021/np200022b
Publication status	Published - 27 May 2011

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@article{0dd595a8f6524d6695ffb352961b2cd1,

title = "Antituberculosis cycloartane triterpenoids from Radermachera boniana",

abstract = "Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain. (Chemical Equation Presented).",

author = "Truong, \{Ngan B.\} and Pham, \{Cuong V.\} and Doan, \{Huong T.M.\} and Nguyen, \{Hung V.\} and Nguyen, \{Cuong M.\} and Nguyen, \{Hiep T.\} and Zhang, \{Hong Jie\} and Fong, \{Harry H.S.\} and Franzblau, \{Scott G.\} and Soejarto, \{Djaja D.\} and Chau, \{Minh V.\}",

note = "This research was supported under the ICBG grants from the Fogarty International Center, NIH, 1-UO1-TW001015-01 (1998-2003), 2-UO1-TW001015-06 (2003-2008), 3U01TW001015-10S1, and 2U01TW001015-11A1, administered by the Fogarty International Center as part of an International Cooperative Biodiversity Groups (ICBG) program, through funds from NIH, NSF, and Foreign Agricultural Service of the USDA.",

year = "2011",

month = may,

day = "27",

doi = "10.1021/np200022b",

language = "English",

volume = "74",

pages = "1318--1322",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Antituberculosis cycloartane triterpenoids from Radermachera boniana

AU - Truong, Ngan B.

AU - Pham, Cuong V.

AU - Doan, Huong T.M.

AU - Nguyen, Hung V.

AU - Nguyen, Cuong M.

AU - Nguyen, Hiep T.

AU - Zhang, Hong Jie

AU - Fong, Harry H.S.

AU - Franzblau, Scott G.

AU - Soejarto, Djaja D.

AU - Chau, Minh V.

N1 - This research was supported under the ICBG grants from the Fogarty International Center, NIH, 1-UO1-TW001015-01 (1998-2003), 2-UO1-TW001015-06 (2003-2008), 3U01TW001015-10S1, and 2U01TW001015-11A1, administered by the Fogarty International Center as part of an International Cooperative Biodiversity Groups (ICBG) program, through funds from NIH, NSF, and Foreign Agricultural Service of the USDA.

PY - 2011/5/27

Y1 - 2011/5/27

N2 - Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain. (Chemical Equation Presented).

AB - Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α- boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain. (Chemical Equation Presented).

UR - https://www.scopus.com/pages/publications/79957797853

U2 - 10.1021/np200022b

DO - 10.1021/np200022b

M3 - Journal article

C2 - 21469696

AN - SCOPUS:79957797853

SN - 0163-3864

VL - 74

SP - 1318

EP - 1322

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Antituberculosis cycloartane triterpenoids from Radermachera boniana

Abstract

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