Antimycobacterial Naphthopyrones from Senna obliqua

James G. Graham, Hongjie ZHANG, Susan L. Pendland, Bernard D. Santarsiero, Andrew D. Mesecar, Fernando Cabieses, Norman R. Farnsworth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Bioactivity-directed fractionation of the methanolic extract of the stem and fruits of Senna obliqua led to the isolation of two known antimycobacterial natural products, quinquangulin (1) and rubrofusarin (2). Both compounds had minimum inhibitory concentrations (MICs) of 12.0 μg/mL against Mycobacteria tuberculosis in radiometric culture. This is the first report of antimycobacterial activity associated with naphthopyrone compounds. Their structures were determined by spectroscopic means including 1D and 2D NMR techniques and further confirmed by X-ray crystallographic analysis.

Original languageEnglish
Pages (from-to)225-227
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 2004

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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