Antimycobacterial Naphthopyrones from Senna obliqua

James G. Graham; Hongjie Zhang; Susan L. Pendland; Bernard D. Santarsiero; Andrew D. Mesecar; Fernando Cabieses; Norman R. Farnsworth

doi:10.1021/np030348i

Antimycobacterial Naphthopyrones from Senna obliqua

James G. Graham, Hongjie Zhang, Susan L. Pendland, Bernard D. Santarsiero, Andrew D. Mesecar, Fernando Cabieses, Norman R. Farnsworth^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

42 Citations (Scopus)

Abstract

Bioactivity-directed fractionation of the methanolic extract of the stem and fruits of Senna obliqua led to the isolation of two known antimycobacterial natural products, quinquangulin (1) and rubrofusarin (2). Both compounds had minimum inhibitory concentrations (MICs) of 12.0 μg/mL against Mycobacteria tuberculosis in radiometric culture. This is the first report of antimycobacterial activity associated with naphthopyrone compounds. Their structures were determined by spectroscopic means including 1D and 2D NMR techniques and further confirmed by X-ray crystallographic analysis.

Original language	English
Pages (from-to)	225-227
Number of pages	3
Journal	Journal of Natural Products
Volume	67
Issue number	2
DOIs	https://doi.org/10.1021/np030348i
Publication status	Published - Feb 2004

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np030348i

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title = "Antimycobacterial Naphthopyrones from Senna obliqua",

abstract = "Bioactivity-directed fractionation of the methanolic extract of the stem and fruits of Senna obliqua led to the isolation of two known antimycobacterial natural products, quinquangulin (1) and rubrofusarin (2). Both compounds had minimum inhibitory concentrations (MICs) of 12.0 μg/mL against Mycobacteria tuberculosis in radiometric culture. This is the first report of antimycobacterial activity associated with naphthopyrone compounds. Their structures were determined by spectroscopic means including 1D and 2D NMR techniques and further confirmed by X-ray crystallographic analysis.",

author = "Graham, {James G.} and Hongjie Zhang and Pendland, {Susan L.} and Santarsiero, {Bernard D.} and Mesecar, {Andrew D.} and Fernando Cabieses and Farnsworth, {Norman R.}",

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AU - Graham, James G.

AU - Zhang, Hongjie

AU - Pendland, Susan L.

AU - Santarsiero, Bernard D.

AU - Mesecar, Andrew D.

AU - Cabieses, Fernando

AU - Farnsworth, Norman R.

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AB - Bioactivity-directed fractionation of the methanolic extract of the stem and fruits of Senna obliqua led to the isolation of two known antimycobacterial natural products, quinquangulin (1) and rubrofusarin (2). Both compounds had minimum inhibitory concentrations (MICs) of 12.0 μg/mL against Mycobacteria tuberculosis in radiometric culture. This is the first report of antimycobacterial activity associated with naphthopyrone compounds. Their structures were determined by spectroscopic means including 1D and 2D NMR techniques and further confirmed by X-ray crystallographic analysis.

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ER -

Antimycobacterial Naphthopyrones from Senna obliqua

Abstract

Scopus Subject Areas

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