@article{d17f7c6105934e769be7b4cdbe7f5ea4,
title = "Antimalarial compounds from Rhaphidophora decursiva",
abstract = "Bioassay-directed fractionation led to the isolation of 14 compounds, six of which possess antimalarial activity, from the dried leaves and stems of Rhaphidophora decursiva. Polysyphorin (1) and rhaphidecurperoxin (6) showed strong activities against Plasmodium falciparum. Rhaphidecursinol A (2), rhaphidecursinol B (3), grandisin (4), and epigrandisin (5) were less active against the same organism. Among the isolates, rhaphidecursinol A (2) and rhaphidecursinol B (3) were determined to be new neolignans, and rhaphidecurperoxin (6) is a new benzoperoxide. Known compounds isolated include polysyphorin (1), grandisin (4), epigrandisin (5), (+)-medioresinol, (-)-pinoresinol, (-)-syringaresinol, (+)-glaberide I, (+)-dehydrovomifoliol, (-)-liliolide, (-)-hydroxydihydrobovolide, and N-butylbenzamide, of which compound 1 appears worthy of further evaluation as an antimalarial agent. Structure elucidation and identification were accomplished by spectroscopic means including 1D and 2D NMR analyses.",
author = "Hongjie Zhang and Tamez, {P. A.} and Hoang, {V. D.} and Tan, {G. T.} and Hung, {N. V.} and Xuan, {L. T.} and Huong, {L. M.} and Cuong, {N. M.} and Thao, {D. T.} and Soejarto, {D. D.} and Fong, {H. H.S.} and Pezzuto, {J. M.}",
note = "The first collection and initial antimalarial evaluation sample of R. decursiva was made under a grant from the MacArthur Foundation (Grant 96-44652, 1997-1999) as part of a collaborative research project between the National Center for Science and Technology (Hanoi), the Cuc Phuong National Park, the Hanoi College of Pharmacy (Hanoi), and the University of Illinois at Chicago. Re-collections of samples in larger quantities, taxonomic identification of samples, bioassay-guided chemical isolation, and structure elucidation work presented in this paper were made under a grant administered by the Fogarty International Center, NIH (Grant 1 UO1-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) program.15 Permits for the collection of samples of R. decursiva and its export from Vietnam were granted by the Ministry of Agriculture and Rural Development, Hanoi, Vietnam, through a letter dated September 15, 1998, Ref. No. 3551/BNN/KHCN, and from the Cuc Phuong National Park, through a letter dated September 16, 1998. ",
year = "2001",
month = jun,
day = "1",
doi = "10.1021/np010037c",
language = "English",
volume = "64",
pages = "772--777",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "6",
}