TY - JOUR
T1 - Antimalarial compounds from Grewia bilamellata
AU - Ma, Cuiying
AU - ZHANG, Hongjie
AU - Ghee, Teng Tan
AU - Van Hung, Nguyen
AU - Nguyen, Manh Cuong
AU - Soejarto, D. Doel
AU - Fong, Harry H.S.
N1 - This project was supported by NIH Grant 1 U01TW01015-01, administered by the Fogarty International Center as part of an International Cooperative Biodiversity Groups (ICBG) program, through funds from NIH, NSF, and Foreign Agricultural Service of the USDA. The permit for the collection and export of plant material for this study was granted by the Ministry of Agriculture and Rural Development, Hanoi, Vietnam, through a letter dated September 15, 1998, Ref. No. 3551/BNN/KHCN, and from the Cuc Phuong National Park, through a letter dated September 16, 1998.
PY - 2006/3
Y1 - 2006/3
N2 - Bioassay-directed fractionation led to the isolation of 12 compounds from a sample of the dried leaves, twigs, and stems of Grewia bilamellata. Five of the isolates, 3α,20-lupandiol (1), grewin (2), nitidanin (4), 2α,3β-dihydroxyolean-12-en-28-oic acid (5), and 2,6-dimethoxy-1-acetonylquinol (6), showed varying degrees of in vitro antimalarial activity against Plasmodium falciparum, but were devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line. Of the 12 isolates, compounds 1, 2, and 3 (bilagrewin) were determined to be a new triterpene, a new coumarinolignan, and a new neolignan, respectively. Other known compounds isolated in this study were 8-O-4′ neolignan guaiacylglycerol-β-coniferyl ether isomers (threo and erythro), cleomiscosin D, icariol A2, ciwujiatone, and daucosterol. The structures of 1-3 were elucidated and identified on the basis of spectroscopic data including 1D and 2D NMR analysis.
AB - Bioassay-directed fractionation led to the isolation of 12 compounds from a sample of the dried leaves, twigs, and stems of Grewia bilamellata. Five of the isolates, 3α,20-lupandiol (1), grewin (2), nitidanin (4), 2α,3β-dihydroxyolean-12-en-28-oic acid (5), and 2,6-dimethoxy-1-acetonylquinol (6), showed varying degrees of in vitro antimalarial activity against Plasmodium falciparum, but were devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line. Of the 12 isolates, compounds 1, 2, and 3 (bilagrewin) were determined to be a new triterpene, a new coumarinolignan, and a new neolignan, respectively. Other known compounds isolated in this study were 8-O-4′ neolignan guaiacylglycerol-β-coniferyl ether isomers (threo and erythro), cleomiscosin D, icariol A2, ciwujiatone, and daucosterol. The structures of 1-3 were elucidated and identified on the basis of spectroscopic data including 1D and 2D NMR analysis.
UR - http://www.scopus.com/inward/record.url?scp=33645992430&partnerID=8YFLogxK
U2 - 10.1021/np050313d
DO - 10.1021/np050313d
M3 - Journal article
C2 - 16562832
AN - SCOPUS:33645992430
SN - 0163-3864
VL - 69
SP - 346
EP - 350
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 3
ER -
