Antimalarial compounds from Grewia bilamellata

Cuiying Ma, Hongjie ZHANG, Teng Tan Ghee, Nguyen Van Hung, Manh Cuong Nguyen, D. Doel Soejarto, Harry H.S. Fong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

64 Citations (Scopus)


Bioassay-directed fractionation led to the isolation of 12 compounds from a sample of the dried leaves, twigs, and stems of Grewia bilamellata. Five of the isolates, 3α,20-lupandiol (1), grewin (2), nitidanin (4), 2α,3β-dihydroxyolean-12-en-28-oic acid (5), and 2,6-dimethoxy-1-acetonylquinol (6), showed varying degrees of in vitro antimalarial activity against Plasmodium falciparum, but were devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line. Of the 12 isolates, compounds 1, 2, and 3 (bilagrewin) were determined to be a new triterpene, a new coumarinolignan, and a new neolignan, respectively. Other known compounds isolated in this study were 8-O-4′ neolignan guaiacylglycerol-β-coniferyl ether isomers (threo and erythro), cleomiscosin D, icariol A2, ciwujiatone, and daucosterol. The structures of 1-3 were elucidated and identified on the basis of spectroscopic data including 1D and 2D NMR analysis.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalJournal of Natural Products
Issue number3
Publication statusPublished - Mar 2006

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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