Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Hongjie ZHANG; Pamela A. Tamez; Zeynep Aydogmus; Ghee Teng Tan; Yoko Saikawa; Kimiko Hashimoto; Masaya Nakata; Nguyen Van Hung; Le Thi Xuan; Nguyen Manh Cuong; D. Doel Soejarto; John M. Pezzuto; Harry H.S. Fong

doi:10.1055/s-2002-36350

Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Hongjie ZHANG
, Pamela A. Tamez
, Zeynep Aydogmus
, Ghee Teng Tan
, Yoko Saikawa
, Kimiko Hashimoto
, Masaya Nakata
, Nguyen Van Hung
, Le Thi Xuan
, Nguyen Manh Cuong
, D. Doel Soejarto
, John M. Pezzuto
, Harry H.S. Fong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

57 Citations (Scopus)

Abstract

Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC₅₀ values below 1 ng/ml.

Original language	English
Pages (from-to)	1088-1091
Number of pages	4
Journal	Planta Medica
Volume	68
Issue number	12
DOIs	https://doi.org/10.1055/s-2002-36350
Publication status	Published - 1 Dec 2002

User-Defined Keywords

Antimalarial activity
Araceae
Bioassay-directed fractionation
Ficus fistulosa
Moraceae
Rhaphidophora decursiva
Roridin E
Trichothecene sesquiterpenoids
Verrucarin L acetate

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10.1055/s-2002-36350

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@article{4a027f82417d40c08c7b69b96879e099,

title = "Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva",

abstract = "Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.",

keywords = "Antimalarial activity, Araceae, Bioassay-directed fractionation, Ficus fistulosa, Moraceae, Rhaphidophora decursiva, Roridin E, Trichothecene sesquiterpenoids, Verrucarin L acetate",

author = "Hongjie ZHANG and Tamez, \{Pamela A.\} and Zeynep Aydogmus and Tan, \{Ghee Teng\} and Yoko Saikawa and Kimiko Hashimoto and Masaya Nakata and Hung, \{Nguyen Van\} and Xuan, \{Le Thi\} and Cuong, \{Nguyen Manh\} and Soejarto, \{D. Doel\} and Pezzuto, \{John M.\} and Fong, \{Harry H.S.\}",

note = "This work was supported by a grant administered by the Fogarty International Center, NIH (U01-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) (2). ",

year = "2002",

month = dec,

day = "1",

doi = "10.1055/s-2002-36350",

language = "English",

volume = "68",

pages = "1088--1091",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "12",

}

TY - JOUR

T1 - Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

AU - ZHANG, Hongjie

AU - Tamez, Pamela A.

AU - Aydogmus, Zeynep

AU - Tan, Ghee Teng

AU - Saikawa, Yoko

AU - Hashimoto, Kimiko

AU - Nakata, Masaya

AU - Hung, Nguyen Van

AU - Xuan, Le Thi

AU - Cuong, Nguyen Manh

AU - Soejarto, D. Doel

AU - Pezzuto, John M.

AU - Fong, Harry H.S.

N1 - This work was supported by a grant administered by the Fogarty International Center, NIH (U01-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) (2).

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.

AB - Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.

KW - Antimalarial activity

KW - Araceae

KW - Bioassay-directed fractionation

KW - Ficus fistulosa

KW - Moraceae

KW - Rhaphidophora decursiva

KW - Roridin E

KW - Trichothecene sesquiterpenoids

KW - Verrucarin L acetate

UR - https://www.scopus.com/pages/publications/0036969333

U2 - 10.1055/s-2002-36350

DO - 10.1055/s-2002-36350

M3 - Journal article

C2 - 12494335

AN - SCOPUS:0036969333

SN - 0032-0943

VL - 68

SP - 1088

EP - 1091

JO - Planta Medica

JF - Planta Medica

IS - 12

ER -

Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

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