Abstract
Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.
Original language | English |
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Pages (from-to) | 1088-1091 |
Number of pages | 4 |
Journal | Planta Medica |
Volume | 68 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Dec 2002 |
Scopus Subject Areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
User-Defined Keywords
- Antimalarial activity
- Araceae
- Bioassay-directed fractionation
- Ficus fistulosa
- Moraceae
- Rhaphidophora decursiva
- Roridin E
- Trichothecene sesquiterpenoids
- Verrucarin L acetate