Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Hongjie ZHANG, Pamela A. Tamez, Zeynep Aydogmus, Ghee Teng Tan, Yoko Saikawa, Kimiko Hashimoto, Masaya Nakata, Nguyen Van Hung, Le Thi Xuan, Nguyen Manh Cuong, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.

Original languageEnglish
Pages (from-to)1088-1091
Number of pages4
JournalPlanta Medica
Volume68
Issue number12
DOIs
Publication statusPublished - 1 Dec 2002

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

User-Defined Keywords

  • Antimalarial activity
  • Araceae
  • Bioassay-directed fractionation
  • Ficus fistulosa
  • Moraceae
  • Rhaphidophora decursiva
  • Roridin E
  • Trichothecene sesquiterpenoids
  • Verrucarin L acetate

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