@article{a007ddefcb9b4a67bdbb85d756c19c47,
title = "Antimalarial agents from plants II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva",
abstract = "Antimalarial bioassay-directed fractionation led to the isolation of a new active indole alkaloid, decursivine (1), from the leaves and stems of Rhaphidophora decursiva Schott (Araceae). In addition, a leaf sample yielded the structurally-related compound serotobenine (2), previously reported from a taxonomically unrelated family, which was not active against Plasmodium falciparum. The structure of 1 was elucidated by spectroscopic means, and its antimalarial activity was observed with IC50 values of 3.93 and 4.41 μg/ml against the D6 and W2 clones of Plasmodium falciparum, respectively.",
keywords = "2D NMR, Antimalarial activity, Araceae, Bioassay-directed fractionation, Decursivine, Indole alkaloid, Rhaphidophora decursiva",
author = "Hongjie Zhang and Shengxiang Qiu and Pamela Tamez and Tan, \{Ghee Teng\} and Zeynep Aydogmus and \{Van Hung\}, Nguyen and Cuong, \{Nguyen Manh\} and Cindy Angerhofer and Soejarto, \{D. Doel\} and Pezzuto, \{John M.\} and Fong, \{Harry H.S.\}",
note = "Funding Information: The initial collection and antimalarial evaluation of the leaves (SV5005) of R. decursiva was supported by NIH grant (R29 AI34408). Subsequent to sample SVA5005, the bioassay-guided isolation and structure elucidation of decur-sivine (1) presented in this paper were funded by a grant administered by the Fogarty International Center, NIH (UO1-TW01015-01), as part of an International Cooperative Biodiversity Group (ICBG) program (Soejarto et al., 1999). The authors wish to acknowledge the Research Resources Center, University of Illinois at Chicago for access to the Bruker DRX 500 MHz instrument for this study and to the Mass Spectrometry Service Lab, Department of Chemistry, University of Minnesota for the acquisition of the MS data. P.A.T. is the recipient of a pre-doctoral fellowship by the American Foundation for Pharmaceutical Education.",
year = "2002",
doi = "10.1076/phbi.40.3.221.5832",
language = "English",
volume = "40",
pages = "221--224",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Taylor and Francis Ltd.",
number = "3",
}