Antimalarial agents from plants II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva

Hongjie ZHANG, Shengxiang Qiu, Pamela Tamez, Ghee Teng Tan, Zeynep Aydogmus, Nguyen Van Hung, Nguyen Manh Cuong, Cindy Angerhofer, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

Antimalarial bioassay-directed fractionation led to the isolation of a new active indole alkaloid, decursivine (1), from the leaves and stems of Rhaphidophora decursiva Schott (Araceae). In addition, a leaf sample yielded the structurally-related compound serotobenine (2), previously reported from a taxonomically unrelated family, which was not active against Plasmodium falciparum. The structure of 1 was elucidated by spectroscopic means, and its antimalarial activity was observed with IC50 values of 3.93 and 4.41 μg/ml against the D6 and W2 clones of Plasmodium falciparum, respectively.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalPharmaceutical Biology
Volume40
Issue number3
DOIs
Publication statusPublished - 2002

Scopus Subject Areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • 2D NMR
  • Antimalarial activity
  • Araceae
  • Bioassay-directed fractionation
  • Decursivine
  • Indole alkaloid
  • Rhaphidophora decursiva

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