@article{f8e4d269c244410386ac3ff5c8d5c882,
title = "Antifungal study of substituted 4-pyridylmethylene-4′-aniline Schiff bases",
abstract = "Otomycosis is a superficial infection of the ear caused by fungi. The disease may occur in the pinna, external auditory canal and tympanic membrane of humans and animals. Aspergillus Niger and Candida albicans are the most prevalent fungal species responsible for otomycosis. In our study, the potential antifungal properties of a series of Schiff bases was examined. The synthesized compounds (1-14) were investigated for their minimum inhibitory concentration, minimum fungicidal concentration and zone of clearance against Aspergillus Niger and Candida albicans. Compounds 5 and 6 with alkyl chain containing 6 or 7 carbon atoms exhibited an obvious fungicidal activity with the MIC/MFC ratio of 2. Zone of clearance study also demonstrated that both compounds 5 and 6 produced noticeable clear zones against the tested fungi as compared to fluconazole. The time-kill kinetic study showed that Candida albicans colonies were reduced by more than 3 logs after 24 h exposure to compound 5 at 4 and 8 × MIC levels. Both compounds 5 and 6 at a concentration of 50 μg mL-1 exhibited satisfactory cell viability towards human skin keratinocytes. Our results suggest that these compounds may be considered as potential drug candidates for the treatment of Aspergillus Niger and Candida albicans ear infections.",
author = "Lam, {P. L.} and Lee, {K. K.H.} and Kok, {S. H.L.} and R. Gambari and Lam, {K. H.} and HO, {Cheuk Lam} and X. Ma and Lo, {Y. H.} and WONG, {Wai Yeung} and Dong, {Q. C.} and Zhaoxiang BIAN and CHUI, {Chung Hin}",
note = "This work was supported by the Innovation Technology Commission to ABCT, HKPU, and the account codes: FRG1/14-15/021, FRG1/14-15/078 and 3840116 (C.-H. Chui) as well as 0316176 (X.-Z. Bian). R. Gambari was supported by AIRC (IG13575). We thank the National Natural Science Foundation of China (project number: 51373145), Hong Kong Research Grants Council (HKBU12304715), Areas of Excellence Scheme of HKSAR (AoE/P-03/08), the Science, Technology and Innovation Committee of Shenzhen Municipality (JCYJ20140419130507116 and JCYJ20140818163041143) for financial support. The work was also supported by Partner State Key Laboratory of Environmental and Biological Analysis and Strategic Development Fund of HKBU. Y.-H. Lo gratefully acknowledges the financial support from the National Science Council of Taiwan (NSC 102-2113-M-845-001) and the project of the specific research fields in the University of Taipei, Taiwan. Q. Dong thanks the financial support from the National Natural Science Foundation of China (61307030), the Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi (OIT), Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province, the Natural Science Foundation for Young Scientists of Shanxi Province, China (2014021019-2) and the Outstanding Young Scholars Cultivating Program.",
year = "2016",
doi = "10.1039/c6ra20186e",
language = "English",
volume = "6",
pages = "104575--104581",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "106",
}