Antibacterial effects of a monoporphyrinato ytterbium(III) complex and its free components on Staphylococcus aureus as determined by stop-flow microcalorimetry

An Xin Hou*, Zhi Xue, Yi Liu, Song Sheng Qu, Rick W K WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The antibacterial effect of Yb3+, the free porphyrin base 5,10,15,20-tetrakis(4-methoxyphenyl)porpbyrin (H2TMP; 1), and the corresponding Yb3+ porphyrinato complex [YbIII(TMP)(H2O)3] +Cl-(Yb(TMP); 2) towards Staphylococcus aureus was investigated by stop-flow microcalorimetry. By analyzing the obtained metabolic thermogenic curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC50), and generation time (tG) were determined. The antibacterial activities of the three compounds tested was 2 > 1 > Yb3+, with an IC50 value of 273 mg/l for complex 2. The Yb3+ porphyrinato complex is proposed to benefit from synergetic effects of Yb3+ and the free porphyrin 1.

Original languageEnglish
Pages (from-to)1492-1500
Number of pages9
JournalChemistry and Biodiversity
Volume4
Issue number7
DOIs
Publication statusPublished - 2007

Scopus Subject Areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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