Antibacterial effects of a monoporphyrinato ytterbium(III) complex and its free components on Staphylococcus aureus as determined by stop-flow microcalorimetry

An Xin Hou; Zhi Xue; Yi Liu; Song Sheng Qu; Rick W K WONG

doi:10.1002/cbdv.200790128

Antibacterial effects of a monoporphyrinato ytterbium(III) complex and its free components on Staphylococcus aureus as determined by stop-flow microcalorimetry

An Xin Hou^*, Zhi Xue, Yi Liu, Song Sheng Qu, Rick W K WONG

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

19 Citations (Scopus)

Abstract

The antibacterial effect of Yb³⁺, the free porphyrin base 5,10,15,20-tetrakis(4-methoxyphenyl)porpbyrin (H₂TMP; 1), and the corresponding Yb³⁺ porphyrinato complex [Yb^III(TMP)(H₂O)₃] ⁺Cl^-(Yb(TMP); 2) towards Staphylococcus aureus was investigated by stop-flow microcalorimetry. By analyzing the obtained metabolic thermogenic curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC₅₀), and generation time (t_G) were determined. The antibacterial activities of the three compounds tested was 2 > 1 > Yb³⁺, with an IC₅₀ value of 273 mg/l for complex 2. The Yb³⁺ porphyrinato complex is proposed to benefit from synergetic effects of Yb³⁺ and the free porphyrin 1.

Original language	English
Pages (from-to)	1492-1500
Number of pages	9
Journal	Chemistry and Biodiversity
Volume	4
Issue number	7
DOIs	https://doi.org/10.1002/cbdv.200790128
Publication status	Published - 2007

Scopus Subject Areas

Bioengineering
Biochemistry
General Chemistry
Molecular Medicine
Molecular Biology

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title = "Antibacterial effects of a monoporphyrinato ytterbium(III) complex and its free components on Staphylococcus aureus as determined by stop-flow microcalorimetry",

abstract = "The antibacterial effect of Yb3+, the free porphyrin base 5,10,15,20-tetrakis(4-methoxyphenyl)porpbyrin (H2TMP; 1), and the corresponding Yb3+ porphyrinato complex [YbIII(TMP)(H2O)3] +Cl-(Yb(TMP); 2) towards Staphylococcus aureus was investigated by stop-flow microcalorimetry. By analyzing the obtained metabolic thermogenic curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC50), and generation time (tG) were determined. The antibacterial activities of the three compounds tested was 2 > 1 > Yb3+, with an IC50 value of 273 mg/l for complex 2. The Yb3+ porphyrinato complex is proposed to benefit from synergetic effects of Yb3+ and the free porphyrin 1.",

author = "Hou, {An Xin} and Zhi Xue and Yi Liu and Qu, {Song Sheng} and WONG, {Rick W K}",

year = "2007",

doi = "10.1002/cbdv.200790128",

language = "English",

volume = "4",

pages = "1492--1500",

journal = "Chemistry and Biodiversity",

issn = "1612-1872",

publisher = "Wiley-Blackwell",

number = "7",

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TY - JOUR

T1 - Antibacterial effects of a monoporphyrinato ytterbium(III) complex and its free components on Staphylococcus aureus as determined by stop-flow microcalorimetry

AU - Hou, An Xin

AU - Xue, Zhi

AU - Liu, Yi

AU - Qu, Song Sheng

AU - WONG, Rick W K

PY - 2007

Y1 - 2007

N2 - The antibacterial effect of Yb3+, the free porphyrin base 5,10,15,20-tetrakis(4-methoxyphenyl)porpbyrin (H2TMP; 1), and the corresponding Yb3+ porphyrinato complex [YbIII(TMP)(H2O)3] +Cl-(Yb(TMP); 2) towards Staphylococcus aureus was investigated by stop-flow microcalorimetry. By analyzing the obtained metabolic thermogenic curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC50), and generation time (tG) were determined. The antibacterial activities of the three compounds tested was 2 > 1 > Yb3+, with an IC50 value of 273 mg/l for complex 2. The Yb3+ porphyrinato complex is proposed to benefit from synergetic effects of Yb3+ and the free porphyrin 1.

AB - The antibacterial effect of Yb3+, the free porphyrin base 5,10,15,20-tetrakis(4-methoxyphenyl)porpbyrin (H2TMP; 1), and the corresponding Yb3+ porphyrinato complex [YbIII(TMP)(H2O)3] +Cl-(Yb(TMP); 2) towards Staphylococcus aureus was investigated by stop-flow microcalorimetry. By analyzing the obtained metabolic thermogenic curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC50), and generation time (tG) were determined. The antibacterial activities of the three compounds tested was 2 > 1 > Yb3+, with an IC50 value of 273 mg/l for complex 2. The Yb3+ porphyrinato complex is proposed to benefit from synergetic effects of Yb3+ and the free porphyrin 1.

UR - http://www.scopus.com/inward/record.url?scp=34547511496&partnerID=8YFLogxK

U2 - 10.1002/cbdv.200790128

DO - 10.1002/cbdv.200790128

M3 - Journal article

C2 - 17638330

AN - SCOPUS:34547511496

SN - 1612-1872

VL - 4

SP - 1492

EP - 1500

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 7

ER -

Antibacterial effects of a monoporphyrinato ytterbium(III) complex and its free components on Staphylococcus aureus as determined by stop-flow microcalorimetry

Abstract

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