Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue

Kim Hung Lam*, Kenneth Ka Ho Lee, Roberto Gambari, Stanton Hon Lung Kok, Tsz Wai Kok, Albert Sun Chi Chan, Zhaoxiang BIAN, Wai Yeung WONG, Raymond Siu Ming Wong, Fung Yi Lau, See Wai Tong, Kit Wah Chan, Chor Hing Cheng, Chung Hin CHUI, Johnny Cheuk On Tang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.

Original languageEnglish
Pages (from-to)877-882
Number of pages6
JournalPhytomedicine
Volume21
Issue number6
DOIs
Publication statusPublished - 15 May 2014

Scopus Subject Areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • Alkaloid analogues
  • Anti-tumour
  • Galipea longiflora

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