@article{193478965370482ab0098d55867a8117,
title = "Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue",
abstract = "The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.",
keywords = "Alkaloid analogues, Anti-tumour, Galipea longiflora",
author = "Lam, {Kim Hung} and Lee, {Kenneth Ka Ho} and Roberto Gambari and Kok, {Stanton Hon Lung} and Kok, {Tsz Wai} and Chan, {Albert Sun Chi} and Zhaoxiang Bian and Wong, {Wai Yeung} and Wong, {Raymond Siu Ming} and Lau, {Fung Yi} and Tong, {See Wai} and Chan, {Kit Wah} and Cheng, {Chor Hing} and Chui, {Chung Hin} and Tang, {Johnny Cheuk On}",
note = "Funding Information: We acknowledge the financial support from HKBU (38-40-116 and 30-13-135 (FRG1/13-14/035) to Dr. C-H Chui), HKPU (UC11, to Dr. K-H Lam and Dr. J. C-O Tang), AIRC (IG-13575 to Prof. R Gambari) and a research fund between Innovation Technology Commission, Research Grants Council and Hong Kong Polytechnic University. Special thank is given to Professor K.K-H Lee who provided financial support to the animal experiments and housing fee. We also thank Dr. P. Chan who assisted to synthesize the compound.",
year = "2014",
month = may,
day = "15",
doi = "10.1016/j.phymed.2014.02.005",
language = "English",
volume = "21",
pages = "877--882",
journal = "Phytomedicine",
issn = "0944-7113",
publisher = "Elsevier",
number = "6",
}
