Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue

Kim Hung Lam; Kenneth Ka Ho Lee; Roberto Gambari; Stanton Hon Lung Kok; Tsz Wai Kok; Albert Sun Chi Chan; Zhaoxiang Bian; Wai Yeung Wong; Raymond Siu Ming Wong; Fung Yi Lau; See Wai Tong; Kit Wah Chan; Chor Hing Cheng; Chung Hin Chui; Johnny Cheuk On Tang

doi:10.1016/j.phymed.2014.02.005

Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue

Kim Hung Lam^*, Kenneth Ka Ho Lee, Roberto Gambari, Stanton Hon Lung Kok, Tsz Wai Kok, Albert Sun Chi Chan, Zhaoxiang Bian, Wai Yeung Wong, Raymond Siu Ming Wong, Fung Yi Lau, See Wai Tong, Kit Wah Chan, Chor Hing Cheng, Chung Hin Chui, Johnny Cheuk On Tang

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

17 Citations (Scopus)

Abstract

The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.

Original language	English
Pages (from-to)	877-882
Number of pages	6
Journal	Phytomedicine
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.phymed.2014.02.005
Publication status	Published - 15 May 2014

Scopus Subject Areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

User-Defined Keywords

Alkaloid analogues
Anti-tumour
Galipea longiflora

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2014.02.005

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Lam, K. H., Lee, K. K. H., Gambari, R., Kok, S. H. L., Kok, T. W., Chan, A. S. C., Bian, Z., Wong, W. Y., Wong, R. S. M., Lau, F. Y., Tong, S. W., Chan, K. W., Cheng, C. H., Chui, C. H., & Tang, J. C. O. (2014). Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue. Phytomedicine, 21(6), 877-882. https://doi.org/10.1016/j.phymed.2014.02.005

@article{193478965370482ab0098d55867a8117,

title = "Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue",

abstract = "The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.",

keywords = "Alkaloid analogues, Anti-tumour, Galipea longiflora",

author = "Lam, {Kim Hung} and Lee, {Kenneth Ka Ho} and Roberto Gambari and Kok, {Stanton Hon Lung} and Kok, {Tsz Wai} and Chan, {Albert Sun Chi} and Zhaoxiang Bian and Wong, {Wai Yeung} and Wong, {Raymond Siu Ming} and Lau, {Fung Yi} and Tong, {See Wai} and Chan, {Kit Wah} and Cheng, {Chor Hing} and Chui, {Chung Hin} and Tang, {Johnny Cheuk On}",

note = "Funding Information: We acknowledge the financial support from HKBU (38-40-116 and 30-13-135 (FRG1/13-14/035) to Dr. C-H Chui), HKPU (UC11, to Dr. K-H Lam and Dr. J. C-O Tang), AIRC (IG-13575 to Prof. R Gambari) and a research fund between Innovation Technology Commission, Research Grants Council and Hong Kong Polytechnic University. Special thank is given to Professor K.K-H Lee who provided financial support to the animal experiments and housing fee. We also thank Dr. P. Chan who assisted to synthesize the compound.",

year = "2014",

month = may,

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doi = "10.1016/j.phymed.2014.02.005",

language = "English",

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Lam, KH, Lee, KKH, Gambari, R, Kok, SHL, Kok, TW, Chan, ASC, Bian, Z, Wong, WY, Wong, RSM, Lau, FY, Tong, SW, Chan, KW, Cheng, CH, Chui, CH & Tang, JCO 2014, 'Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue', Phytomedicine, vol. 21, no. 6, pp. 877-882. https://doi.org/10.1016/j.phymed.2014.02.005

TY - JOUR

T1 - Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue

AU - Lam, Kim Hung

AU - Lee, Kenneth Ka Ho

AU - Gambari, Roberto

AU - Kok, Stanton Hon Lung

AU - Kok, Tsz Wai

AU - Chan, Albert Sun Chi

AU - Bian, Zhaoxiang

AU - Wong, Wai Yeung

AU - Wong, Raymond Siu Ming

AU - Lau, Fung Yi

AU - Tong, See Wai

AU - Chan, Kit Wah

AU - Cheng, Chor Hing

AU - Chui, Chung Hin

AU - Tang, Johnny Cheuk On

N1 - Funding Information: We acknowledge the financial support from HKBU (38-40-116 and 30-13-135 (FRG1/13-14/035) to Dr. C-H Chui), HKPU (UC11, to Dr. K-H Lam and Dr. J. C-O Tang), AIRC (IG-13575 to Prof. R Gambari) and a research fund between Innovation Technology Commission, Research Grants Council and Hong Kong Polytechnic University. Special thank is given to Professor K.K-H Lee who provided financial support to the animal experiments and housing fee. We also thank Dr. P. Chan who assisted to synthesize the compound.

PY - 2014/5/15

Y1 - 2014/5/15

N2 - The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.

AB - The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.

KW - Alkaloid analogues

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SN - 0944-7113

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JF - Phytomedicine

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ER -

Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue

Abstract

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