TY - JOUR
T1 - Anti-inflammatory and antiproliferative prenylated chalcones from Hedysarum gmelinii
AU - Liu, Yi
AU - Zhang, Jun
AU - Wen, Ran
AU - Tu, Guang Zhong
AU - Chen, Hubiao
AU - Liang, Hong
AU - Zhao, Yu Ying
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China [grant number 20672007].
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Five new prenylated chalcones hedysarumines C-G (1–5), along with eight known chalcones (6–13) all of which were isolated from the genus Hedysarum for the first time, were isolated from the roots of Hedysarum gmelinii by chromatographic methods. Their structures were determined by extensive spectroscopic techniques. The isolated chalcones (2–13) and previously isolated prenylated chalcones (14–16) were evaluated for antiproliferative activity against five human cancer cell lines (HepG2, A549, Du145, BGC823, and HCT116) and in vitro anti-inflammatory activity. Compounds 5, 10, and 15 inhibited NO production induced by lipopolysaccharide in BV-2 cells, with IC 50 values ranging from 3.25 to 8.48 μM. Compounds 4 and 11 showed moderate antiproliferative activity to selective human cancer cell lines, with the IC 50 values of 4 and 11 against A549 cell line being 7.79 and 9.67 μM, respectively, and the IC 50 value of 11 against HCT116 cell line being 8.85 μM.
AB - Five new prenylated chalcones hedysarumines C-G (1–5), along with eight known chalcones (6–13) all of which were isolated from the genus Hedysarum for the first time, were isolated from the roots of Hedysarum gmelinii by chromatographic methods. Their structures were determined by extensive spectroscopic techniques. The isolated chalcones (2–13) and previously isolated prenylated chalcones (14–16) were evaluated for antiproliferative activity against five human cancer cell lines (HepG2, A549, Du145, BGC823, and HCT116) and in vitro anti-inflammatory activity. Compounds 5, 10, and 15 inhibited NO production induced by lipopolysaccharide in BV-2 cells, with IC 50 values ranging from 3.25 to 8.48 μM. Compounds 4 and 11 showed moderate antiproliferative activity to selective human cancer cell lines, with the IC 50 values of 4 and 11 against A549 cell line being 7.79 and 9.67 μM, respectively, and the IC 50 value of 11 against HCT116 cell line being 8.85 μM.
KW - anti-inflammatory activity
KW - antiproliferative activity
KW - Hedysarum gmelinii
KW - Leguminosae
KW - prenylated chalcones
UR - http://www.scopus.com/inward/record.url?scp=85044440943&partnerID=8YFLogxK
U2 - 10.1080/10286020.2018.1450390
DO - 10.1080/10286020.2018.1450390
M3 - Journal article
C2 - 29589472
AN - SCOPUS:85044440943
SN - 1028-6020
VL - 20
SP - 1009
EP - 1018
JO - Journal of Asian Natural Products Research
JF - Journal of Asian Natural Products Research
IS - 11
ER -