Anti-inflammatory and antiproliferative prenylated chalcones from Hedysarum gmelinii

Yi Liu, Jun Zhang, Ran Wen, Guang Zhong Tu, Hubiao CHEN, Hong Liang*, Yu Ying Zhao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Five new prenylated chalcones hedysarumines C-G (1–5), along with eight known chalcones (6–13) all of which were isolated from the genus Hedysarum for the first time, were isolated from the roots of Hedysarum gmelinii by chromatographic methods. Their structures were determined by extensive spectroscopic techniques. The isolated chalcones (2–13) and previously isolated prenylated chalcones (14–16) were evaluated for antiproliferative activity against five human cancer cell lines (HepG2, A549, Du145, BGC823, and HCT116) and in vitro anti-inflammatory activity. Compounds 5, 10, and 15 inhibited NO production induced by lipopolysaccharide in BV-2 cells, with IC 50 values ranging from 3.25 to 8.48 μM. Compounds 4 and 11 showed moderate antiproliferative activity to selective human cancer cell lines, with the IC 50 values of 4 and 11 against A549 cell line being 7.79 and 9.67 μM, respectively, and the IC 50 value of 11 against HCT116 cell line being 8.85 μM.

Original languageEnglish
Pages (from-to)1009-1018
Number of pages10
JournalJournal of Asian Natural Products Research
Volume20
Issue number11
DOIs
Publication statusPublished - 2 Nov 2018

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

User-Defined Keywords

  • anti-inflammatory activity
  • antiproliferative activity
  • Hedysarum gmelinii
  • Leguminosae
  • prenylated chalcones

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