Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips

Guang Qin Zhang, Xiao Dong Huang, Hui Wang, Alexander Kai Nan Leung, Chi Leung Chan, David W F Fong, Zhiling Yu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

53 Citations (Scopus)


This study aimed to assess the anti-inflammatory and analgesic effects of Fructus Rosae Multiflorae (FRM, hips of Rosa multiflora Thunb.). FRM was extracted with 75% ethanol and the dried extract (FRME) was administered intragastrically (i.g.) at 100, 200 and 400 mg/kg. The anti-inflammatory effect was evaluated in four experimental animal models and analgesic effect in two animal models. Pretreatment with a single dose of FRME produced significant dose-dependent anti-inflammatory effects on carrageenin-induced rat hind paw edema, xylene-induced mouse ear edema and acetic acid-induced mouse vascular permeation. In a 7-day study, daily administration of FRME suppressed cotton pellet-induced rat granuloma formation. Pretreatment with a single dose of FRME also produced dose-dependent anti-nociceptive effects in thermally- and chemically induced mouse pain models. In addition, a single dose of FRME at 2.4 g/kg body weight (equivalent to 87.6 g of dried hips per kg body weight) produced no observable acute toxicity in mice within seven days. These results demonstrate that FRME possesses anti-inflammatory and analgesic effects and has no obvious acute toxicity, which advanced our understanding of the folk use of FRM in treating various inflammatory disorders.

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalJournal of Ethnopharmacology
Issue number2
Publication statusPublished - 23 Jul 2008

Scopus Subject Areas

  • Pharmacology
  • Drug Discovery

User-Defined Keywords

  • Anti-inflammatory effects
  • Anti-inflammatory plants
  • Anti-nociceptive effects
  • Medicinal plants
  • Rosaceae


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