TY - JOUR
T1 - Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips
AU - Zhang, Guang Qin
AU - Huang, Xiao Dong
AU - Wang, Hui
AU - Leung, Alexander Kai Nan
AU - Chan, Chi Leung
AU - Fong, David W F
AU - Yu, Zhiling
N1 - Funding Information:
This work was supported by a China Pharmaceutical University grant (211052) and a grant from the Natural Science Foundation of Jiangsu Province, China (BK2004112).
PY - 2008/7/23
Y1 - 2008/7/23
N2 - This study aimed to assess the anti-inflammatory and analgesic effects of Fructus Rosae Multiflorae (FRM, hips of Rosa multiflora Thunb.). FRM was extracted with 75% ethanol and the dried extract (FRME) was administered intragastrically (i.g.) at 100, 200 and 400 mg/kg. The anti-inflammatory effect was evaluated in four experimental animal models and analgesic effect in two animal models. Pretreatment with a single dose of FRME produced significant dose-dependent anti-inflammatory effects on carrageenin-induced rat hind paw edema, xylene-induced mouse ear edema and acetic acid-induced mouse vascular permeation. In a 7-day study, daily administration of FRME suppressed cotton pellet-induced rat granuloma formation. Pretreatment with a single dose of FRME also produced dose-dependent anti-nociceptive effects in thermally- and chemically induced mouse pain models. In addition, a single dose of FRME at 2.4 g/kg body weight (equivalent to 87.6 g of dried hips per kg body weight) produced no observable acute toxicity in mice within seven days. These results demonstrate that FRME possesses anti-inflammatory and analgesic effects and has no obvious acute toxicity, which advanced our understanding of the folk use of FRM in treating various inflammatory disorders.
AB - This study aimed to assess the anti-inflammatory and analgesic effects of Fructus Rosae Multiflorae (FRM, hips of Rosa multiflora Thunb.). FRM was extracted with 75% ethanol and the dried extract (FRME) was administered intragastrically (i.g.) at 100, 200 and 400 mg/kg. The anti-inflammatory effect was evaluated in four experimental animal models and analgesic effect in two animal models. Pretreatment with a single dose of FRME produced significant dose-dependent anti-inflammatory effects on carrageenin-induced rat hind paw edema, xylene-induced mouse ear edema and acetic acid-induced mouse vascular permeation. In a 7-day study, daily administration of FRME suppressed cotton pellet-induced rat granuloma formation. Pretreatment with a single dose of FRME also produced dose-dependent anti-nociceptive effects in thermally- and chemically induced mouse pain models. In addition, a single dose of FRME at 2.4 g/kg body weight (equivalent to 87.6 g of dried hips per kg body weight) produced no observable acute toxicity in mice within seven days. These results demonstrate that FRME possesses anti-inflammatory and analgesic effects and has no obvious acute toxicity, which advanced our understanding of the folk use of FRM in treating various inflammatory disorders.
KW - Anti-inflammatory effects
KW - Anti-inflammatory plants
KW - Anti-nociceptive effects
KW - Medicinal plants
KW - Rosaceae
UR - http://www.scopus.com/inward/record.url?scp=45449087497&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2008.04.014
DO - 10.1016/j.jep.2008.04.014
M3 - Journal article
C2 - 18515025
AN - SCOPUS:45449087497
SN - 0378-8741
VL - 118
SP - 290
EP - 294
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -