Anti-inflammatory activity of polysaccharide from Schizophyllum commune as affected by ultrasonication

Bin Du, Huansong Zeng, Yuedong Yang, Zhaoxiang BIAN, Baojun Xu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

66 Citations (Scopus)


Ultrasound treatment was applied to modify the physicochemical properties of an exopolysaccharide from mycelial culture of Schizophyllum commune. Molecular weight (MW) degradation, viscosity and anti-inflammatory property of ultrasonic treated polysaccharide were optimized with response surface methodology. The best ultrasonic parameters were obtained with a three-variable-three-level Box-Behnken design. The optimized conditions for efficient anti-inflammatory activity are initial concentration at 0.4%, ultrasonic power at 600 W, and duration of ultrasonic irradiation for 9 min. Under these conditions, the nitric oxide inhibition rate was 95 ± 0.03% which agreed closely with the predicted value (96%). Average MW of polysaccharide decreased after ultrasonic treatments. The viscosity of degraded polysaccharide dropped compared with native polysaccharide. The anti-inflammatory activity was improved by ultrasound treatment. The results suggested that ultrasound treatment is an effective approach to decrease the MW of polysaccharide with high anti-inflammatory activity. Ultrasonic treatment is a viable modification technology for high MW polymer materials.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalInternational Journal of Biological Macromolecules
Publication statusPublished - 1 Oct 2016

Scopus Subject Areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

User-Defined Keywords

  • Anti-inflammatory
  • Response surface methodology
  • Ultrasonic treatment


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