Anti-HIV lignans from Schisandra micrantha

Rong Tao Li, Quan Bin Han, Yong Tang Zheng, Rui Rui Wang, Liu Meng Yang, Li Yan Peng, Wei Lie Xiao, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

10 Citations (Scopus)


Aim: To find new natural compounds with anti-HIV activity from Schisandra micrantha. Methord: The chemical constituents of Schisandra micrantha were isolated by various column chromatographic methods. Their structures were assigned by spectroscopic methods including 2D NMR experiments, and their anti-HIV-1 activities and cytotoxicities were tested by microtiter syncytium formation infectivity assay. Result: Four lignans, micrantherin A (1), gomisin K3 (2), gomisin G (3), and vladinol F (4) were isolated from the leaves and stems of Schisandra micrantha. Vladinol F (4) was found to show potent anti-HIV-1 activity with IC50 value of 3.51 μg/mL and a selective index of 27.45. Conclusion: Micrantherin A (1) was a new lignan.
Original languageEnglish
Pages (from-to)208-212
Number of pages5
JournalChinese Journal of Natural Medicines
Issue number4
Publication statusPublished - 20 Jul 2005

Scopus Subject Areas

  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • Anti-HIV-1 activity
  • Lignan
  • Micrantherin A
  • Schisandra micrantha
  • Schisandraceae


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