Abstract
Aim: To find new natural compounds with anti-HIV activity from Schisandra micrantha. Methord: The chemical constituents of Schisandra micrantha were isolated by various column chromatographic methods. Their structures were assigned by spectroscopic methods including 2D NMR experiments, and their anti-HIV-1 activities and cytotoxicities were tested by microtiter syncytium formation infectivity assay. Result: Four lignans, micrantherin A (1), gomisin K3 (2), gomisin G (3), and vladinol F (4) were isolated from the leaves and stems of Schisandra micrantha. Vladinol F (4) was found to show potent anti-HIV-1 activity with IC50 value of 3.51 μg/mL and a selective index of 27.45. Conclusion: Micrantherin A (1) was a new lignan.
| Original language | English |
|---|---|
| Pages (from-to) | 208-212 |
| Number of pages | 5 |
| Journal | Chinese Journal of Natural Medicines |
| Volume | 3 |
| Issue number | 4 |
| Publication status | Published - 20 Jul 2005 |
Scopus Subject Areas
- Drug Discovery
- Complementary and alternative medicine
User-Defined Keywords
- Anti-HIV-1 activity
- Lignan
- Micrantherin A
- Schisandra micrantha
- Schisandraceae
