Anti-HIV lignans from Justicia procumbens

Xin-Ya Xu; Dong-Ying Wang; Chuen-Fai Ku; Yang Zhao; Han Cheng; Kang-Lun Liu; Li-Jun Rong; Hong-Jie Zhang

doi:10.1016/S1875-5364(19)30117-7

Anti-HIV lignans from Justicia procumbens

Xin-Ya Xu
, Dong-Ying Wang
, Chuen-Fai Ku
, Yang Zhao
, Han Cheng
, Kang-Lun Liu
, Li-Jun Rong
, Hong-Jie Zhang^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

28 Citations (Scopus)

Abstract

Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC₅₀ value of 5.27 μmol·L⁻¹ and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC₅₀ values of 4.95 (SI > 6.2) and 0.38 μmol·L⁻¹ (SI = 5.3), respectively.

Original language	English
Pages (from-to)	945-952
Number of pages	8
Journal	Chinese Journal of Natural Medicines
Volume	17
Issue number	12
DOIs	https://doi.org/10.1016/S1875-5364(19)30117-7
Publication status	Published - Dec 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Anti-HIV-1 activity
Antiviral plant
Justicia procumbens
Lignans

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10.1016/S1875-5364(19)30117-7

http://www.cjnmcpu.com/en/article/id/7644fce0-18de-45ea-ba92-81f83dc3f7a8

Cite this

@article{a326b32d13f042f787b668f6ef9efbf1,

title = "Anti-HIV lignans from Justicia procumbens",

abstract = "Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L−1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI > 6.2) and 0.38 μmol·L−1 (SI = 5.3), respectively.",

keywords = "Anti-HIV-1 activity, Antiviral plant, Justicia procumbens, Lignans",

author = "Xin-Ya Xu and Dong-Ying Wang and Chuen-Fai Ku and Yang Zhao and Han Cheng and Kang-Lun Liu and Li-Jun Rong and Hong-Jie Zhang",

note = "Funding Information: [Received on] 08-Oct.-2019 [Research funding] This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region, China (Nos. HKBU12103618 and HKBU12103917), the Research Grants Council of the Hong Kong Baptist University (HKBU), Interdisciplinary Research Matching Scheme (No. RC-IRMS/15-16/02), the Hong Kong Scholars Program Foundation (No. XJ2015047), and Mr. Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund (WANG Dong-Ying). [*Corresponding author] Tel: 852-34112956, E-mail: zhanghj@hkbu. edu.hk (ZHANG Hong-Jie); Tel: 1-312-3550203, E-mail: [email protected] (RONG Li-Jun) ΔThese authors contributed equally to this work. These authors have no conflict of interest to declare. Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday Published by Elsevier B.V. All rights reserved",

year = "2019",

month = dec,

doi = "10.1016/S1875-5364(19)30117-7",

language = "English",

volume = "17",

pages = "945--952",

journal = "Chinese Journal of Natural Medicines",

issn = "2095-6975",

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T1 - Anti-HIV lignans from Justicia procumbens

AU - Xu, Xin-Ya

AU - Wang, Dong-Ying

AU - Ku, Chuen-Fai

AU - Zhao, Yang

AU - Cheng, Han

AU - Liu, Kang-Lun

AU - Rong, Li-Jun

AU - Zhang, Hong-Jie

N1 - Funding Information: [Received on] 08-Oct.-2019 [Research funding] This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region, China (Nos. HKBU12103618 and HKBU12103917), the Research Grants Council of the Hong Kong Baptist University (HKBU), Interdisciplinary Research Matching Scheme (No. RC-IRMS/15-16/02), the Hong Kong Scholars Program Foundation (No. XJ2015047), and Mr. Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund (WANG Dong-Ying). [*Corresponding author] Tel: 852-34112956, E-mail: zhanghj@hkbu. edu.hk (ZHANG Hong-Jie); Tel: 1-312-3550203, E-mail: [email protected] (RONG Li-Jun) ΔThese authors contributed equally to this work. These authors have no conflict of interest to declare. Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday Published by Elsevier B.V. All rights reserved

PY - 2019/12

Y1 - 2019/12

N2 - Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L−1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI > 6.2) and 0.38 μmol·L−1 (SI = 5.3), respectively.

AB - Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L−1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI > 6.2) and 0.38 μmol·L−1 (SI = 5.3), respectively.

KW - Anti-HIV-1 activity

KW - Antiviral plant

KW - Justicia procumbens

KW - Lignans

UR - https://www.scopus.com/pages/publications/85076673988

U2 - 10.1016/S1875-5364(19)30117-7

DO - 10.1016/S1875-5364(19)30117-7

M3 - Journal article

C2 - 31882050

AN - SCOPUS:85076673988

SN - 2095-6975

VL - 17

SP - 945

EP - 952

JO - Chinese Journal of Natural Medicines

JF - Chinese Journal of Natural Medicines

IS - 12

ER -

Anti-HIV lignans from Justicia procumbens

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