@article{a326b32d13f042f787b668f6ef9efbf1,
title = "Anti-HIV lignans from Justicia procumbens",
abstract = "Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L−1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI > 6.2) and 0.38 μmol·L−1 (SI = 5.3), respectively.",
keywords = "Anti-HIV-1 activity, Antiviral plant, Justicia procumbens, Lignans",
author = "Xin-Ya Xu and Dong-Ying Wang and Chuen-Fai Ku and Yang Zhao and Han Cheng and Kang-Lun Liu and Li-Jun Rong and Hong-Jie Zhang",
note = "Funding Information: [Received on] 08-Oct.-2019 [Research funding] This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region, China (Nos. HKBU12103618 and HKBU12103917), the Research Grants Council of the Hong Kong Baptist University (HKBU), Interdisciplinary Research Matching Scheme (No. RC-IRMS/15-16/02), the Hong Kong Scholars Program Foundation (No. XJ2015047), and Mr. Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund (WANG Dong-Ying). [*Corresponding author] Tel: 852-34112956, E-mail: zhanghj@hkbu. edu.hk (ZHANG Hong-Jie); Tel: 1-312-3550203, E-mail:
[email protected] (RONG Li-Jun) ΔThese authors contributed equally to this work. These authors have no conflict of interest to declare. Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday Published by Elsevier B.V. All rights reserved",
year = "2019",
month = dec,
doi = "10.1016/S1875-5364(19)30117-7",
language = "English",
volume = "17",
pages = "945--952",
journal = "Chinese Journal of Natural Medicines",
issn = "2095-6975",
publisher = "China Pharmaceutical University",
number = "12",
}
