Anti-HIV lignans from Justicia procumbens

Xin Ya XU, Dong Ying WANG, Chuen Fai KU, Yang ZHAO, Han CHENG, Kang Lun LIU, Li Jun RONG, Hongjie ZHANG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L−1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI > 6.2) and 0.38 μmol·L−1 (SI = 5.3), respectively.

Original languageEnglish
Pages (from-to)945-952
Number of pages8
JournalChinese Journal of Natural Medicines
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2019

Scopus Subject Areas

  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • Anti-HIV-1 activity
  • Antiviral plant
  • Justicia procumbens
  • Lignans

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