Anti-Cancer Effects of Pristimerin and the Mechanisms: A Critical Review

Jia Jun Li, Yan Yan Yan, Hong Mei Sun, Yun Liu, Chao Yue Su, Hubiao CHEN, Jian Ye Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

As a quinonemethide triterpenoid extracted from species of the Celastraceae and Hippocrateaceae, pristimerin has been shown potent anti-cancer effects. Specifically, it was found that pristimerin can affect many tumor-related processes, such as apoptosis, autophagy, migration and invasion, vasculogenesis, and drug resistance. Various molecular targets or signaling pathways are also involved, such as cyclins, reactive oxygen species (ROS), microRNA, nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and PI3K/AKT/mammalian target of rapamycin (mTOR) pathways. In this review, we will focus on the research about pristimerin-induced anti-cancer activities to achieve a deeper understanding of the targets and mechanisms, which offer evidences suggesting that pristimerin can be a potent anti-cancer drug.

Original languageEnglish
Article number746
JournalFrontiers in Pharmacology
Volume10
DOIs
Publication statusPublished - 12 Jul 2019

Scopus Subject Areas

  • Pharmacology
  • Pharmacology (medical)

User-Defined Keywords

  • anti-cancer
  • apoptosis
  • autophagy
  • mechanism
  • molecular target
  • pharmaceutical effect
  • pristimerin

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