Anisotropic α-Fe2O3/AgAu/Polydopamine Nanostructures for Photothermally Enhanced Antibacterial Applications

Qunling Fang*, Jing Wang, Qingshan Xiong, Yunqi Xu, Guangjin Yu*, Ailing Hui, Ken Cham Fai Leung, Shouhu Xuan*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

Multifunctional photothermal nanomaterials offer notable opportunities for antimicrobial therapy due to their excellent antibacterial activities without leading to drug resistance. Herein, we report a facile one-step strategy for fabricating anisotropic corn-like α-Fe2O3/AgAu/polydopamine (PDA) nanospindles with photothermally enhanced antibacterial performance. The AgAu bimetallic nanocrystals sandwiched between the α-Fe2O3 core and the PDA shell are achieved by simultaneous reduction from AgNO3 and HAuCl4 during the oxidative polymerization of dopamine and galvanic replacement reaction between the obtained Ag nanocrystals and Au precursor. The inner nanostructure and atom ratio of AgAu bimetallic nanocrystals can be modulated by varying the experimental parameter, thus further controlling the photothermal activities. In comparison to α-Fe2O3/Au/PDA, Fe2O3/Ag1.7Au0.8/PDA (50 μg/mL) has a better photothermal conversion effect (60.69%). Moreover, the α-Fe2O3/Ag1.7Au0.8/PDA nanospindle exhibits moderate antibacterial activity, which may be derived from Ag+ release. Under application of near-infrared light irradiation, the corn-like α-Fe2O3/Ag1.7Au0.8/PDA nanospindles (50 μg/mL) exhibit a photothermally enhanced sterilization effect against both Escherichia coli and Staphylococcus aureus (99.99%). This “Ag+ release-photothermal” coupling sterilization method provides a simple synergistic antimicrobial therapy strategy, which possesses great promise for future nanomedicine against bacteria in water treatment.

Original languageEnglish
Pages (from-to)6423-6434
Number of pages12
JournalACS Applied Nano Materials
Volume6
Issue number7
Early online date4 Apr 2023
DOIs
Publication statusPublished - 14 Apr 2023

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • Ag+
  • antimicrobial
  • core/shell
  • nanospindle
  • photothermal

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