Angiosuppressive properties of marine-derived compounds—a mini review

Patrick Y K YUE*, H. M. Leung, Adela J. Li, Tracy N.C. Chan, Tsz Shan Lum, Y. L. Chung, Y. H. Sung, Ming Hung WONG, Kelvin S Y LEUNG, Eddy Y. Zeng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Angiogenesis, formation of new blood vessels from preexisting one, is a critical step of tumorgenesis of solid tumors. Therefore, antiangiogenic therapy is one of the promising approaches to control tumor growth. In the past 20 years, a lot of compounds have been tested for their antiangiogenic properties. Bevacizumab, Avastin®, the first antiangiogenic drug approved by the US FDA, has been widely used in clinic for treating cancer. Indeed, many synthetic compounds are highly toxic and exert side effects even though they are effective in inhibiting neovessel formation and cancer cell growth. Using natural compounds or their derivatives is one of the ways to solve these problems. Sinomenine and ginsenosides are common antiangiogenic and anticancer compounds that are extracted from herbal medicines. Recent findings suggested that marine algae-derived natural pigments also possess similar activities. It has been reported that fucoxanthin from Undaria pinnatifida, Siphonaxanthin from Codium fragile, can inhibit angiogenesis and cancer growth effectively. In conclusion, natural compounds derived from marine algae could provide a novel and safe source for new drug development in anticancer and antiangiogenic properties in the future.

Original languageEnglish
Pages (from-to)8990-9001
Number of pages12
JournalEnvironmental Science and Pollution Research
Volume24
Issue number10
DOIs
Publication statusPublished - 1 Apr 2017

Scopus Subject Areas

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Angiogenesis
  • Angiosuppression
  • Marine-derived compound

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